Methoxypolyethylene Glycol Amine CAS 80506-64-5

Chemical Name: Methoxypolyethylene glycol amine
CAS No.: 80506-64-5
Molecular Fomula:  C5H13NO2 Chemical Structure:
Molecular weight: 119.16222
Appearance: White powder

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Table of Contents

Methoxypolyethylene Glycol Amine (CAS 80506-64-5) Specifications

Technical Parameters

Property Specification Comparison with mPEG-SH Comparison with mPEG-COOH
Molecular Weight Range 350 Da – 40,000 Da Similar molecular flexibility Higher amine reactivity
Purity ≥95% (HPLC) Comparable purity standards Superior conjugation efficiency
End Group Functionality Primary amine (-NH2) Thiol group (-SH) Carboxylic acid (-COOH)

Storage & Handling

Store at -20°C under nitrogen atmosphere. Shelf life: 24 months when properly stored. Incompatible with strong oxidizing agents.

Functional Applications

Pharmaceutical Applications

1. Drug conjugation for enhanced solubility
2. PEGylation of therapeutic proteins
3. Nanocarrier surface functionalization

Biotechnology Uses

• Biomolecule immobilization
• Diagnostic probe modification
• Tissue engineering scaffolds

Implementation Case Studies

Case 1: Targeted Drug Delivery System

Challenge: Improve tumor accumulation of chemotherapeutic agent
Solution: Conjugated mPEG-NH2 (5,000 Da) to nanoparticle surface
Result: 68% increase in circulation half-life

Case 2: Protein Stabilization

Challenge: Prevent enzyme aggregation
Method: Site-specific PEGylation using CAS 80506-64-5
Outcome: Maintained 92% activity after 6-month storage

Client Implementation Examples

Pharma Client A: Novel ADC Development

Application: Antibody-drug conjugate linker
Molecular Weight: 2,000 Da
Scale: 15kg batch production
Result: Achieved DAR 3.8 with 98% purity

Biotech Client B: Diagnostic Kit Enhancement

Use: Lateral flow assay modification
Specification: 10,000 Da MW
Performance: Increased detection sensitivity by 40%

Technical Consultation & Ordering

Contact our PEGylation experts for:
• Custom molecular weight options
• Bulk production requests
• Technical documentation support

Email: info@vivalr.com
Phone: (86) 15866781826

Request Product Documentation

Available upon request:
• COA (Certificate of Analysis)
• MSDS (Material Safety Data Sheet)
• Custom synthesis protocols

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