Benserazide hydrochloride CAS 14919-77-8

Benserazide Hydrochloride (CAS 14919-77-8) Comprehensive User Guide

Table of Contents

• 1. Product Specifications & Comparative Analysis
• 2. Detailed Applications & Mechanisms
• 3. Clinical & Industrial Usage Scenarios
• 4. Customer Case Studies
• 5. Technical Inquiry & Purchasing Guidance

1. Product Specifications & Comparative Analysis

Key Advantage: Superior peripheral decarboxylase inhibition with 2:1 optimal L-DOPA ratio vs Carbidopa’s 4:1 ratio.

2. Detailed Applications & Mechanisms

2.1 Pharmaceutical Applications

As a peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor, Benserazide HCl:

• Enhances L-DOPA bioavailability by 70-80% in Parkinson’s therapy
• Reduces peripheral dopamine conversion by 90%
• Enables lower L-DOPA dosages (typical ratio 4:1 L-DOPA:Benserazide)

2.2 Research Applications

• Neuropharmacology studies: Dopaminergic pathway analysis
• Enzyme inhibition kinetics (IC₅₀ = 15 nM for AADC)
• Metabolic pathway mapping in preclinical models

3. Clinical & Industrial Usage Scenarios

3.1 Pharmaceutical Manufacturing

Standard formulation process:

1. Combine with L-DOPA in 1:4 ratio (Benserazide:L-DOPA)
2. Tablet compression at 15-20 kN force
3. Coating with hydroxypropyl methylcellulose (HPMC)

3.2 Research Protocols

Experimental dosing guidelines:

4. Customer Case Studies

4.1 NeuroPharm Solutions Ltd. (UK)

Challenge: Reduce L-DOPA-induced nausea in Phase II trial
Solution: 100 mg Benserazide HCl + 400 mg L-DOPA daily
Outcome: 62% reduction in GI adverse events vs previous formulation

4.2 University Research Team (Germany)

Study: Dopamine metabolism in zebrafish models
Protocol: 0.5 mM Benserazide in embryo medium
Finding: 40% increase in CNS dopamine retention

5. Technical Inquiry & Purchasing Guidance

For batch-specific COA, custom formulations, or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826

Procurement Checklist:
1. Required quantity (grams/kg)
2. Purity requirements
3. Preferred shipment method
4. Regulatory documentation needs