Boron Trifluoride Methanol Complex (CAS 2802-68-8): Technical Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | Boron Trifluoride Methanol Complex | Alternative Catalysts (e.g., BF3-THF) |
|---|---|---|
| CAS Number | 2802-68-8 | 462-34-0 |
| Molecular Formula | CH4BF3O | C4H8BF3O |
| Molecular Weight | 99.85 g/mol | 141.91 g/mol |
| Appearance | Colorless to light yellow liquid | Clear liquid |
| Boiling Point | 58–60°C (4 mmHg) | 65–67°C |
| Storage Requirements | Sealed, moisture-free, below 30°C | Inert atmosphere, -20°C |
Key Advantages: Higher solubility in polar solvents compared to BF3-THF, making it preferable for methanol-based reaction systems.
2. Key Applications
2.1 Organic Synthesis
- Friedel-Crafts Alkylation: Catalyzes electrophilic substitution in aromatic compounds.
- Polymerization: Initiator for cationic polymerization of olefins and epoxides.
- Esterification: Accelerates ester formation in pharmaceutical intermediates.
2.2 Industrial Processes
- Manufacturing of specialty chemicals (e.g., dyes, fragrances).
- Petroleum refining for isomerization reactions.
3. Operational Guidelines
3.1 Handling Procedures
- Use corrosion-resistant equipment (glass/PTFE-lined reactors).
- Maintain nitrogen blanket to prevent moisture ingress.
3.2 Reaction Optimization
- Typical concentration: 10–15% (w/w) in methanol.
- Temperature range: 0–40°C (exothermic reactions require cooling).
4. Safety Protocols
| Hazard Code | Risk Statement | Mitigation Measures |
|---|---|---|
| R20/22 | Harmful if inhaled/swallowed | Use fume hood; avoid ingestion |
| R34 | Causes severe burns | Wear acid-resistant PPE |
First Aid: Flush eyes/skin with water for 15 minutes; seek immediate medical attention for ingestion.
5. Industry Use Cases
5.1 Pharmaceutical Production
Client: Major API manufacturer in Wuhan
Application: Synthesis of antihypertensive drug intermediates via regioselective alkylation.
5.2 Polymer Research
Client: European materials science institute
Application: Development of cationic polyolefins with controlled molecular weights.
6. Procurement & Technical Inquiry
Available in 100 mL to 500 mL sealed amber glass bottles. Custom concentrations available upon request.
Contact for MSDS & Pricing:
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