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Specialized in1-Hydroxy-7-azabenzotriazole CAS 39968-33-7and related product development and production

Chemical Name: 1-Hydroxy-7-azabenzotriazole
CAS No.: 39968-33-7
Molecular Fomula: C5H4N4O
Molecular weight: 136.11
Appearance: white powder
Assay: ≥98.0%

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

Table of Contents

1-Hydroxy-7-azabenzotriazole (HOAt) CAS 39968-33-7: Technical Specifications

Core Parameters

Parameter HOAt Specification HOBt Comparison EDC·HCl Comparison
Molecular Formula C6H5N4O C6H5N3O C8H17N3·HCl
Molecular Weight 148.13 g/mol 135.12 g/mol 191.70 g/mol
Appearance White crystalline powder Off-white powder White crystalline
Solubility DMSO, DMF (>50 mg/mL) Limited in DCM Water soluble
Optimal pH Range 4.5-6.5 (peptide synthesis) 5.0-7.0 4.0-6.5

Structural Advantages

HOAt's nitrogen-rich bicyclic structure enables superior activation of carboxyl groups compared to traditional coupling agents. The 7-aza modification enhances nucleophilicity while maintaining thermal stability up to 150°C.

2. Industrial Applications of HOAt

Pharmaceutical Synthesis

As critical component in SPPS (Solid Phase Peptide Synthesis):

  • Reduces racemization to <0.5% in β-lactam antibiotics production
  • Enables high-yield (>85%) coupling in oligonucleotide synthesis
  • Essential for macrocyclization in HCV protease inhibitors

Advanced Material Science

• Corrosion inhibition efficiency: 92-95% in acidic media (pH 2-4)
• Photostabilizer in polymer films: extends UV resistance by 3-5X
• Chelating agent for transition metals in catalytic systems

3. Operational Protocols

Recommended Workflow

1. Dissolve in anhydrous DMF (0.4M concentration)
2. Molar ratio: 1.2 equiv relative to limiting reagent
3. Maintain reaction temperature at 0-5°C during activation
4. Monitor by HPLC (retention time: 3.2-3.5 min)

Safety Handling

• PPE Requirements: Nitrile gloves, chemical goggles
• Storage: -20°C under argon atmosphere
• Shelf Life: 24 months in original packaging

4. Technical Implementation Cases

Case 1: Antiviral Drug Intermediate Synthesis

Client: EU-based CDMO
Challenge: Achieve >90% yield in 32-membered macrocycle formation
Solution: HOAt/HATU system at 0.1M scale
Outcome: 92% isolated yield, reduced dimerization to <2%

Case 2: High-Throughput Peptide Library

Client: US Biotech Startup
Issue: Coupling efficiency drop after 15-mer length
Resolution: HOAt/DIEA in continuous flow reactor
Result: Successful synthesis of 45-mer peptide with 88% purity

5. Verified Client Implementations

Pharmaceutical Manufacturer A (Germany)

• Application: Continuous production of GLP-1 analogs
• Volume: 120kg/month HOAt consumption
• Benefit: Reduced cycle time by 40% vs HOBt protocol

Research Institute B (Japan)

• Project: Development of antimicrobial peptidomimetics
• Usage: 5g-10kg scale over 18 months
• Achievement: 7 patent filings enabled by HOAt chemistry

6. Technical Support & Ordering

Contact Our Chemistry Team

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Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

Does it support auditing?

Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

Whether to provide samples?

Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

User’evaluation of us

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