1. Product Overview & Specifications

5-Methyl-2-pyrazinecarboxylic Acid (CAS 5521-55-1) is a pyrazine derivative widely used in pharmaceutical synthesis and agrochemical research. Below are its key specifications:

2. Applications & Use Cases

Pharmaceutical Intermediates

Used as a key building block in synthesizing antituberculosis agents like PA-824. Its methyl group enhances metabolic stability in APIs.

Agrochemical Development

Integral in creating pyrazine-based fungicides with improved leaf adhesion and rainfastness.

Chemical Research

Serves as a ligand in catalysis and a precursor for metal-organic frameworks (MOFs).

3. Operational Guidelines

Handling Procedures

• Storage: Keep in sealed containers at 2–8°C under inert gas.
• Safety: Use PPE (gloves, goggles) to avoid inhalation/contact.

Synthesis Example

Step 1: React with thionyl chloride (SOCl₂) to form acyl chloride.
Step 2: Couple with isoniazid derivative at 60°C for 4 hours.
Yield: 82–85% with ≥98% purity (HPLC-verified).

4. Customer Case Studies

Case 1: PharmaHealth Solutions

Challenge: Needed a stable intermediate for TB drug scale-up.
Solution: Used CAS 5521-55-1 with optimized coupling conditions.
Result: 20% higher batch consistency and 15% cost reduction.

Case 2: AgroSynth Ltd.

Challenge: Developed rain-resistant fungicide formulations.
Solution: Incorporated methyl-pyrazine moiety for hydrophobicity.
Result: Field efficacy increased by 35% under heavy rainfall.

5. Inquiry & Contact

For technical specifications, bulk pricing, or custom synthesis: