Table of Contents
- 4-Fluoroaniline (CAS 371-40-4) Overview
- Technical Specifications & Comparative Analysis
- Industrial Applications & Use Cases
- Client Success Stories
- Contact for Custom Solutions
4-Fluoroaniline (CAS 371-40-4) Overview
Chemical Profile
| Parameter | Specification |
|---|---|
| Chemical Name | 4-Fluoroaniline |
| CAS Number | 371-40-4 |
| Molecular Formula | C6H6FN |
| Molecular Weight | 111.12 g/mol |
| Appearance | Clear yellow to amber liquid |
| Purity | ≥99% (HPLC) |
| Melting Point | -6°C to -4°C |
| Boiling Point | 187-188°C |
| Density | 1.172 g/cm³ at 25°C |
| Flash Point | 72°C (closed cup) |
| Storage Conditions | 2-8°C in inert atmosphere |
Comparative Analysis with Analogues
| Property | 4-Fluoroaniline | Aniline | 4-Chloroaniline |
|---|---|---|---|
| Electron Withdrawing Effect | Moderate (F) | None | Strong (Cl) |
| Reactivity in Diazotization | High | Medium | Low |
| Pharmaceutical Applications | Antibiotic intermediates | Rubber chemicals | Herbicide production |
| Thermal Stability | Excellent | Good | Fair |
Industrial Applications
Pharmaceutical Intermediates
Critical precursor for fluorinated quinolone antibiotics including Ciprofloxacin and Norfloxacin. Enables precise molecular targeting in antimicrobial agents.
Agrochemical Synthesis
Key component in next-generation fungicides and plant growth regulators. Provides enhanced systemic activity with lower environmental persistence compared to chloro derivatives.
Advanced Material Production
Essential building block for:
• Liquid crystal polymers (LCPs)
• Fluorinated polyimides
• OLED charge transport layers
Dye Manufacturing
Superior chromophore for:
• Acid Orange 156
• Disperse Yellow 211
• UV-stable textile colorants
Client Success Stories
Case Study 1: European Pharma Innovator
| Client Profile | Top 10 EU antibiotic manufacturer |
|---|---|
| Challenge | Improve synthesis yield of Ciprofloxacin intermediate |
| Solution | Optimized 4-fluoroaniline coupling reaction conditions |
| Results | • 22% yield improvement • 15% reduction in side products • Achieved EMA compliance |
Case Study 2: Asian Agrochemical Leader
| Client Profile | USD 800M crop protection specialist |
|---|---|
| Challenge | Develop low-toxicity fungicide formulation |
| Solution | Custom fluorinated aniline derivative synthesis |
| Results | • 40% higher field efficacy • Reduced aquatic toxicity by 65% • Obtained EPA fast-track approval |
Technical Consultation & Ordering
Why Partner with Us?
| Advantage | Benefit |
|---|---|
| Pharma-Grade Quality | EDMF/CEP documentation available |
| Custom Synthesis | From R&D to commercial scale (200MT/month capacity) |
| Regulatory Support | Full REACH, TSCA, K-REACH compliance |
Contact Our Experts
For technical specifications or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
Request product dossier: MSDS, COA, Stability Data, and Application Notes.
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