Chemical Name: Di-p-anisoyl-D-tartaric acid; Di-p-anisoyl-D-tarta
CAS No.: 191605-10-4
Molecular Fomula: C20H18O10
Molecular weight: 418.35
Appearance: White or off-white crystalline powder
Assay：≥99.0%
| Parameter | Value |
|---|---|
| Chemical Name | Di-p-anisoyl-D-tartaric Acid |
| CAS Number | 191605-10-4 |
| Molecular Formula | C₂₀H₂₀O₁₀ |
| Molecular Weight | 420.37 g/mol |
| Appearance | White to off-white crystalline powder |
| Optical Rotation | [α]D²⁰ = +125° to +135° (c=1 in MeOH) |
| Solubility | Soluble in methanol, DMSO; slightly soluble in water |
| Storage | 2-8°C in airtight container |
| Parameter | Di-p-anisoyl-D-tartaric Acid | Di-p-toluoyl-D-tartaric Acid | L-(+)-Tartaric Acid |
|---|---|---|---|
| CAS Number | 191605-10-4 | 32634-68-7 | 87-69-4 |
| Molecular Weight | 420.37 | 392.37 | 150.09 |
| Chiral Resolution Efficiency | High (for amines) | Moderate | Low |
| Solubility in MeOH | ≥50 mg/mL | ≥30 mg/mL | ≥100 mg/mL |
| Optical Purity | ≥99% ee | ≥95% ee | ≥99% ee |
| Pharma Applications | API intermediates, chiral catalysts | Chemical synthesis | Food additives |
Resolve racemic amine compounds in API synthesis (e.g., antidepressants, antihypertensives).
Facilitate enantioselective synthesis of complex molecules in ≤-20°C reactions.
Synthesize enantiopure building blocks for kinase inhibitors and antiviral drugs.
Chiral stationary phase modifier in HPLC columns (0.1-1.0% w/v in mobile phase).
Store under argon at 2-8°C. Equilibrate to room temperature before opening.
Use 1.05-1.2 molar equivalents vs substrate in anhydrous THF/MeCN at -15°C.
Track reaction progress via chiral HPLC (Daicel CHIRALPAK® AD-H column recommended).
Challenge: Resolve racemic sitagliptin intermediate with <95% ee.
Solution: 1.1 eq Di-p-anisoyl-D-tartaric acid in MeOH/water (7:3) at 5°C.
Result: Achieved 99.3% ee with 85% yield; reduced crystallization cycles from 5 to 2.
Challenge: Scale up asymmetric Henry reaction from 10g to 50kg batch.
Solution: 0.5 mol% catalyst in MTBE with slow reagent addition over 8hrs.
Result: Maintained 98.7% ee at 50kg scale with 22% cost reduction vs enzymatic method.
Challenge: Develop novel C-N coupling methodology for tetracyclic alkaloids.
Solution: Chiral induction using 2.0 eq acid in DCM at -40°C.
Result: Published in J. Org. Chem. (2023) with 97% enantiomeric excess achieved.
Contact our chiral chemistry experts for batch-specific COA, regulatory support, and process optimization:
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- ISO 9001-certified production
- Batch-to-batch consistency: ≥99.5% HPLC purity
- Custom salt forms & particle size distribution available
- Regulatory documentation support (DMF, CMC)
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