Di-p-anisoyl-D-tartaric Acid Cas 191605-10-4

Table of Contents

• Product Overview
• Parameter Comparison
• Detailed Applications
• Usage Guidelines
• Case Studies
• Contact for Custom Solutions

Di-p-anisoyl-D-tartaric Acid (CAS 191605-10-4) Overview

Basic Specifications

Comparative Analysis with Similar Chiral Acids

Key Applications in Pharmaceutical & Chemical Industries

1. Chiral Resolution Agent

Resolve racemic amine compounds in API synthesis (e.g., antidepressants, antihypertensives).

2. Asymmetric Catalysis

Facilitate enantioselective synthesis of complex molecules in ≤-20°C reactions.

3. Intermediate Preparation

Synthesize enantiopure building blocks for kinase inhibitors and antiviral drugs.

4. Analytical Chemistry

Chiral stationary phase modifier in HPLC columns (0.1-1.0% w/v in mobile phase).

Operational Guidelines

Step 1: Storage & Handling

Store under argon at 2-8°C. Equilibrate to room temperature before opening.

Step 2: Reaction Setup

Use 1.05-1.2 molar equivalents vs substrate in anhydrous THF/MeCN at -15°C.

Step 3: Process Monitoring

Track reaction progress via chiral HPLC (Daicel CHIRALPAK® AD-H column recommended).

Documented Success Cases

Case 1: Pharmaceutical Manufacturer (Germany)

Challenge: Resolve racemic sitagliptin intermediate with <95% ee.
Solution: 1.1 eq Di-p-anisoyl-D-tartaric acid in MeOH/water (7:3) at 5°C.
Result: Achieved 99.3% ee with 85% yield; reduced crystallization cycles from 5 to 2.

Case 2: Fine Chemical Supplier (China)

Challenge: Scale up asymmetric Henry reaction from 10g to 50kg batch.
Solution: 0.5 mol% catalyst in MTBE with slow reagent addition over 8hrs.
Result: Maintained 98.7% ee at 50kg scale with 22% cost reduction vs enzymatic method.

Case 3: Academic Research (USA)

Challenge: Develop novel C-N coupling methodology for tetracyclic alkaloids.
Solution: Chiral induction using 2.0 eq acid in DCM at -40°C.
Result: Published in J. Org. Chem. (2023) with 97% enantiomeric excess achieved.

Request Custom Technical Solutions

Contact our chiral chemistry experts for batch-specific COA, regulatory support, and process optimization:

Email: info@vivalr.com
Phone: (86) 15866781826

Why Choose Us:
– ISO 9001-certified production
– Batch-to-batch consistency: ≥99.5% HPLC purity
– Custom salt forms & particle size distribution available
– Regulatory documentation support (DMF, CMC)