2-Chlorobutane CAS 78-86-4

Chemical Name: 2-Chlorobutane
Synonyms: sec-Butyl chloride
CAS No.: 78-86-4
Molecular Formula: C4H9Cl
Molecular Weight: 92.57
Appearance: Liquid

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Table of Contents

2-Chlorobutane (CAS 78-86-4) Overview

Chemical Profile

2-Chlorobutane, a halogenated alkane with molecular formula C₄H₉Cl, is widely used in organic synthesis. Key characteristics:

Property Value
Molecular Weight 92.57 g/mol
Boiling Point 68-70°C
Density 0.873 g/cm³
Refractive Index 1.397-1.402

Technical Specifications & Comparison

Parameter 2-Chlorobutane 1-Chlorobutane 2-Chloro-2-methylpropane
Reactivity Moderate High Low
Solubility in Water 0.6 g/L 0.8 g/L 0.3 g/L
Storage Temperature 2-8°C Ambient Below 0°C

Key Industrial Applications

1. Pharmaceutical Intermediates

Used in synthesis of antihistamines and local anesthetics through nucleophilic substitution reactions.

2. Polymer Modification

Acts as chain transfer agent in PVC production (20-50kg per ton polymer).

Operational Guidelines

Aspect Requirement
Ventilation Mandatory fume hood (OSHA Standard 1910.106)
PPE Butyl rubber gloves + Face shield
Spill Management Use vermiculite absorbent

Industry Implementation Cases

Case 1: Pharmaceutical Intermediate Production

Client: European API Manufacturer
Process: Batch alkylation (300L reactor scale)
Yield Improvement: 12% increase vs previous reagent

Verified Client Implementations

Client A: Specialty Chemicals Producer (Germany)

Application: Synthesis of liquid crystal monomers
Consumption: 8MT/month
Purity Requirement: 99.7% (GC analysis)

Client B: Polymer Additives Company (USA)

Process: Production of flame retardant synergists
Result: 18% cost reduction in production

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