N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine CAS 474-74-8

Chemical Name: N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine
CAS No.: 474-74-8
Molecular Fomula: C26H43NO4
Molecular weight: 433.63
Appearance: Solid

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N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine CAS 474-74-8: Comprehensive Product Guide

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter Specification Competitor A Competitor B
CAS Number 474-74-8 474-74-8 N/A
Molecular Formula C₂₆H₄₁NO₄ C₂₆H₄₁NO₄ Similar derivatives
Purity Grade ≥98% (HPLC) 95-97% 90-92%
Storage Conditions 2-8°C in dark Ambient Refrigerated

2. Detailed Applications & Industrial Usage

Pharmaceutical Development

This bile acid derivative demonstrates exceptional utility in hepatic therapeutic research, particularly for:

  • Cholesterol metabolism modulation
  • Nuclear receptor activation studies
  • Enterohepatic circulation analysis

Biochemical Research

Essential for advanced studies in:

  • Membrane permeability assessments
  • Steroid transporter interactions
  • Enzyme kinetics characterization

3. Operational Protocols & Best Practices

Recommended Handling Procedures

  1. Reconstitution: Use anhydrous DMSO at 10 mM concentration
  2. Storage: Aliquot in amber vials under nitrogen atmosphere
  3. Experimental Applications:
    • Cell culture studies: 50-100 μM concentration range
    • In vivo models: 10 mg/kg dosage via IV administration

4. Implementation Case Studies

Case 1: Hepatic Fibrosis Research

Research team at University of California demonstrated 40% reduction in collagen deposition using 75 μM concentration in LX-2 cell lines over 72-hour exposure.

Case 2: Drug Delivery Optimization

PharmaTech Inc. achieved 3.2x bioavailability improvement in oral formulations through molecular conjugation techniques.

5. Client Success Stories

Global Pharma Solutions

Challenge: Needed stable analog for FXR receptor studies
Solution: Custom synthesis with >99% purity
Outcome: Accelerated lead compound identification by 8 months

European Research Consortium

Challenge: Required GMP-grade quantities for clinical trials
Solution: Batch production with full ICH compliance
Outcome: Successful Phase IIa completion with optimal safety profile

6. Expert Consultation & Procurement Guidance

Our technical specialists provide:

  • Custom synthesis scale-up services
  • Regulatory documentation support
  • Application-specific formulation advice

Contact our scientific team:
Email: info@vivalr.com
Phone: (86) 15866781826

Procurement Options

Package Quantity Lead Time
Research Sample 100mg-1g 3-5 business days
Bulk Order 100g-1kg 2-3 weeks
Custom Synthesis 1kg+ 4-6 weeks
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