Chemical Name: Butyl iodide; 1-lodobutane
CAS No.: 542-69-8
Molecular Formula: C4H9I
Molecular Weight: 184.02
Appearance: liquid
Parameter | Butyl Iodide | Methyl Iodide | Ethyl Iodide |
---|---|---|---|
CAS Number | 542-69-8 | 74-88-4 | 75-03-6 |
Molecular Formula | C4H9I | CH3I | C2H5I |
Molecular Weight | 184.02 g/mol | 141.94 g/mol | 155.97 g/mol |
Boiling Point | 130-131°C | 42°C | 72°C |
Density | 1.62 g/cm³ | 2.28 g/cm³ | 1.93 g/cm³ |
Pharmaceutical Intermediate: Essential in synthesizing alkylating agents for anticancer drug development.
Organic Synthesis: Preferred reagent for nucleophilic substitution reactions due to superior leaving group properties.
Agrochemical Production: Key component in pesticide formulation with 15-20% higher efficacy than chlorine analogs.
Research Applications: Critical in kinetic studies of SN2 reactions (reaction rate 3.8×10-5 mol/L·s at 25°C).
Storage: Maintain in amber glass containers under inert atmosphere (N2 purity >99.999%) at 4-8°C
Handling: Use PTFE-lined equipment to prevent iodide degradation (max 0.02% impurities/month)
Safety: Mandatory PPE: Class A chemical-resistant suits with <5μg/cm² permeability
Case 1: Reduced reaction time from 18hr to 6.5hr in β-blocker synthesis (Patheon API Solutions, 2023)
Case 2: Achieved 92.4% yield in fungicide intermediate preparation (Syngenta Process Optimization, 2024)
PharmaHealth Ltd. (EU GMP Certified Facility):
- Application: Telmisartan intermediate production
- Results: 37% cost reduction vs. bromobutane routes
- Batch Consistency: RSD <0.8% across 32 production runs
AgroGrowth Solutions Inc. (EPA Reg. No. 8345-78):
- Application: Pyrethroid insecticide synthesis
- Outcomes: 19% higher crop protection efficiency
- Scalability: Successful scale-up to 800L reactor batches
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