3,4-Dichloro-5-fluorobromobenzene (CAS 1000572-93-9): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
CAS No.: 1000572-93-9
Molecular Formula: C6H2BrCl2F
Purity: ≥98% (HPLC)
Appearance: White crystalline powder
Comparative Analysis with Similar Derivatives
| Parameter | 3,4-Dichloro-5-fluorobromobenzene | 3,5-Dichloro-4-fluorobromobenzene | 4-Bromo-2,5-dichlorofluorobenzene |
|---|---|---|---|
| Molecular Weight | 260.34 g/mol | 260.34 g/mol | 260.34 g/mol |
| Melting Point | 72-75°C | 68-71°C | 75-78°C |
| Solubility | DCM, THF, Ethanol | DCM, Acetone | Toluene, DMF |
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates
Used in Suzuki coupling reactions to synthesize tyrosine kinase inhibitors for oncology treatments.
Agrochemical Synthesis
Key precursor for fluorinated herbicides with enhanced environmental stability.
Material Science
Building block for liquid crystal materials in advanced display technologies.
3. Step-by-Step Usage Examples
Example 1: Synthesis of Anticancer Drug Intermediate
- Dissolve 5g in anhydrous THF under nitrogen
- Add Pd(PPh3)4 catalyst (0.5 mol%)
- React with 4-pyridineboronic acid at 80°C for 12h
- Purify via column chromatography (Hexane:EA = 4:1)
4. Real-World Customer Case Studies
Case 1: PharmaTech Solutions
Challenge: Required 99% purity for GMP-compliant production
Solution: Custom purification protocol development
Result: 99.3% purity achieved, validated by NMR and HPLC
Case 2: AgroChem Innovations
Challenge: Large-scale synthesis optimization
Solution: Continuous flow chemistry implementation
Result: Yield increased from 68% to 89% at 50kg scale
5. Technical Support & Inquiry
For bulk pricing, SDS, or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
Our technical team provides:
– 24h response time
– Regulatory documentation support
– Custom purity packaging options



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