TSTU (CAS 105832-38-0) Comprehensive User Guide: Applications, Case Studies, and Technical Insights
Table of Contents
1. Product Overview & Specifications
TSTU (O-(N-Succinimidyl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate) is a superior peptide coupling reagent (CAS 105832-38-0) with the following properties:
| Parameter | Specification |
|---|---|
| Molecular Formula | C9H16BF4N3O3 |
| Purity | ≥98% (HPLC) |
| Solubility | DMSO, DMF, Acetonitrile |
| Storage | 2-8°C in dry environment |
| Shelf Life | 24 months |
2. Key Applications of TSTU
2.1 Peptide Synthesis
Enables efficient amide bond formation in SPPS (Solid-Phase Peptide Synthesis) with 92-97% activation efficiency.
2.2 Protein Modification
Facilitates NHS ester formation for antibody-drug conjugates (ADCs) with minimal racemization.
4. Comparative Analysis with Similar Reagents
| Reagent | Activation Speed | Byproduct Solubility | Optimal pH Range |
|---|---|---|---|
| TSTU | Fast (5-15 min) | Excellent | 7.5-9.0 |
| HBTU | Moderate (20-30 min) | Good | 8.0-9.5 |
| HATU | Very Fast (2-5 min) | Poor | 6.5-8.5 |
5. Verified Customer Case Studies
Case 1: BioPharma Solutions Inc. (USA)
Application: Large-scale production of GLP-1 analog
Result: Achieved 18% yield improvement vs HBTU with 99.2% purity
Case 2: Shanghai MedChem Co., Ltd.
Application: ADC linker conjugation
Result: Reduced reaction time from 6hr to 45min at 4°C
6. Request Customized Solutions
Contact our peptide synthesis experts:
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