Dexketoprofen Trometamol CAS 156604-79-4: Comprehensive User Guide

1. Product Overview & Specifications

Basic Information

Product Name: Dexketoprofen Trometamol
CAS Number: 156604-79-4
Molecular Formula: C₁₆H₁₅NO₃·C₄H₁₁NO₃
Molecular Weight: 376.39 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥99% (HPLC)
Storage: 2-8°C in airtight containers

Comparative Analysis

2. Key Applications & Uses

Therapeutic Applications

• Acute pain management (post-surgical/dental)
• Chronic inflammatory conditions (osteoarthritis)
• Musculoskeletal disorder treatment

Mechanistic Advantages

As a potent COX-2 inhibitor with 98% protein binding capacity, it demonstrates:
– 2x faster absorption vs racemic ketoprofen
– 30% reduced NSAID-associated gastric toxicity

3. Usage Scenarios & Best Practices

Pharmaceutical Formulation

Typical Dosage Forms:
– Oral tablets (12.5-25mg)
– Lyophilized injections (50mg/vial)
Stability Note: Maintain pH 6.8-7.4 in aqueous solutions

Clinical Protocol

4. Real-World Client Case Studies

Case 1: European Pharma Manufacturer

Challenge: Develop fast-acting NSAID with ≤2% GI adverse events
Solution: 25mg dexketoprofen trometamol oral disintegrating tablets
Outcome: 89% pain reduction within 45 mins (Phase III data)

Case 2: Asian Hospital Network

Challenge: Post-arthroscopy pain management protocol optimization
Solution: IV dexketoprofen (50mg) + multimodal analgesia
Outcome: 40% opioid use reduction, 92% patient satisfaction

5. Request Customized Quotations

Contact our technical team for:
– Bulk pricing (GMP-grade)
– Formulation support
– Regulatory documentation

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