Coluracetam (CAS 135463-81-9): Comprehensive Technical Guide
Table of Contents
1. Key Specifications & Comparative Analysis
| Parameter | Coluracetam | Standard Nootropic |
|---|---|---|
| Chemical Formula | C19H23N3O3 | Variable |
| Molecular Weight | 341.404 g/mol | 200-400 g/mol |
| Melting Point | 225°C | 150-250°C |
| Density | 1.291 g/cm³ | 1.1-1.5 g/cm³ |
2. Clinical Applications & Mechanism
Primary Function: Potent choline uptake enhancer targeting high-affinity choline transporters (HACU) with demonstrated efficacy in:
- Cognitive impairment rehabilitation
- Neurodegenerative disease management
- Visual processing enhancement
Mechanistic Action: Modulates glutamatergic signaling through AMPA receptor potentiation while enhancing cholinergic neurotransmission via improved choline recycling.
3. Administration Protocols
| Application | Dosage Range | Frequency |
|---|---|---|
| Cognitive Support | 10-20 mg | BID-TID |
| Neuroprotection | 20-40 mg | QD |
| Research Use | Custom titration | Protocol-specific |
4. Industry Applications
Validated in multiple sectors:
- Pharmaceutical Development: Lead compound in Alzheimer’s therapeutic research
- Neuropharmacology: Standard reference in cholinergic studies
- Biochemical Research: Tool compound for transporter kinetics analysis
5. Verified Client Implementations
| Organization | Application | Outcome |
|---|---|---|
| MedChemExpress | High-purity reference standard (99.87%) | Validated in 15+ published studies |
| Shanghai ACME | Bulk API production | GMP-certified manufacturing since 2022 |
| Suzhou Fam Pharma | Custom synthesis services | 50+ successful client projects |
Technical & Commercial Inquiries
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