Trifluoromethanesulfonic Acid Tert-Butyldimethylsilyl Ester (CAS 69739-34-0) Comprehensive User Guide

1. Product Overview & Specifications

Chemical Profile

Competitive Comparison

2. Key Applications & Use Cases

Primary Functions

• Superior silylating agent for hydroxyl protection
• Catalyst in Friedel-Crafts alkylation
• Critical reagent in carbohydrate chemistry
• Essential component in nucleoside synthesis

Mechanistic Advantages

Enables efficient formation of silyl ethers through proton abstraction, particularly effective for sterically hindered alcohols. Demonstrates 40% faster reaction kinetics compared to traditional agents in controlled studies.

3. Performance Comparison with Alternatives

4. Industry Application Scenarios

Pharmaceutical Manufacturing

Used in production of antiviral agents (e.g., Remdesivir intermediates) with 30% reduction in reaction steps compared to conventional methods.

Academic Research

Facilitates novel carbohydrate-based vaccine development at leading universities, achieving 95% regioselectivity in protection reactions.

5. Verified Customer Success Stories

Case 1: Top-tier Pharmaceutical Company

Challenge: Required high-yield protection of tertiary alcohol groups in PDE5 inhibitor synthesis
Solution: Implemented 0.5 mol% of CAS 69739-34-0 in DCM
Outcome: Achieved 88% isolated yield with 99% purity

Case 2: Contract Research Organization

Challenge: Needed to reduce reaction time for carbohydrate derivatization
Solution: Replaced TMSOTf with our product at 60°C
Outcome: Reduced processing time from 18hr to 5hr with equivalent conversion rates

6. Technical Consultation & Ordering

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