Isobutyl Chloroformate (CAS 543-27-1): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Isobutyl Chloroformate (CAS 543-27-1) is a highly reactive organochlorine compound widely used in organic synthesis. Below are its key specifications:
| Parameter | Value |
|---|---|
| CAS Number | 543-27-1 |
| Molecular Formula | C5H9ClO2 |
| Molecular Weight | 136.58 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 128-130°C |
| Density | 1.08 g/cm3 |
Comparative Analysis with Similar Chloroformates
| Parameter | Isobutyl Chloroformate | Ethyl Chloroformate | Isopropyl Chloroformate |
|---|---|---|---|
| Reactivity | High | Moderate | Moderate |
| Stability | Stable under inert conditions | Less stable | Moderate stability |
| Applications | Peptide synthesis, agrochemicals | Basic acylations | Pharmaceutical intermediates |
2. Applications of Isobutyl Chloroformate
This compound is critical in:
- Peptide Synthesis: Acts as a coupling agent for amino acids.
- Agrochemicals: Intermediate in herbicide production.
- Pharmaceuticals: Used in carbamate drug formulations.
- Polymer Chemistry: Modifies polycarbonates and polyurethanes.
3. Usage Guidelines & Best Practices
- Always use under inert gas (N2 or Ar) to prevent hydrolysis.
- Store at 2-8°C in airtight containers.
- Handle with PPE: gloves, goggles, and fume hoods.
4. Case Studies
Case 1: Peptide Bond Formation
Used to synthesize a tripeptide (85% yield) by reacting with L-alanine and glycine in THF at 0°C.
Case 2: Herbicide Intermediate
Produced a chlorophenoxyacetic acid derivative for weed control, achieving 92% purity.
5. Client Success Stories
Client A: PharmaTech Solutions
- Application: Synthesis of antibiotic intermediates.
- Result: Reduced reaction time by 40% compared to ethyl derivatives.
Client B: AgroGreen Ltd.
- Application: Production of glyphosate analogs.
- Result: Achieved scalable batches with 98% consistency.
6. Request a Quote
Contact us for pricing, samples, or technical support:
- Email: info@vivalr.com
- Phone: (86) 15866781826
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