Isobutyl chloroformate CAS 543-27-1

Chemical Name: Isobutyl chloroformate
CAS No.: 543-27-1
Molecular Fomula: C5H9ClO2
Molecular weight: 136.58
Appearance: Colorless liquid
Assay: ≥98.0%

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Isobutyl Chloroformate (CAS 543-27-1): Comprehensive User Guide

1. Product Overview & Specifications

Isobutyl Chloroformate (CAS 543-27-1) is a highly reactive organochlorine compound widely used in organic synthesis. Below are its key specifications:

Parameter Value
CAS Number 543-27-1
Molecular Formula C5H9ClO2
Molecular Weight 136.58 g/mol
Appearance Colorless to pale yellow liquid
Boiling Point 128-130°C
Density 1.08 g/cm3

Comparative Analysis with Similar Chloroformates

Parameter Isobutyl Chloroformate Ethyl Chloroformate Isopropyl Chloroformate
Reactivity High Moderate Moderate
Stability Stable under inert conditions Less stable Moderate stability
Applications Peptide synthesis, agrochemicals Basic acylations Pharmaceutical intermediates

2. Applications of Isobutyl Chloroformate

This compound is critical in:

  • Peptide Synthesis: Acts as a coupling agent for amino acids.
  • Agrochemicals: Intermediate in herbicide production.
  • Pharmaceuticals: Used in carbamate drug formulations.
  • Polymer Chemistry: Modifies polycarbonates and polyurethanes.

3. Usage Guidelines & Best Practices

  • Always use under inert gas (N2 or Ar) to prevent hydrolysis.
  • Store at 2-8°C in airtight containers.
  • Handle with PPE: gloves, goggles, and fume hoods.

4. Case Studies

Case 1: Peptide Bond Formation

Used to synthesize a tripeptide (85% yield) by reacting with L-alanine and glycine in THF at 0°C.

Case 2: Herbicide Intermediate

Produced a chlorophenoxyacetic acid derivative for weed control, achieving 92% purity.

5. Client Success Stories

Client A: PharmaTech Solutions

  • Application: Synthesis of antibiotic intermediates.
  • Result: Reduced reaction time by 40% compared to ethyl derivatives.

Client B: AgroGreen Ltd.

  • Application: Production of glyphosate analogs.
  • Result: Achieved scalable batches with 98% consistency.

6. Request a Quote

Contact us for pricing, samples, or technical support:

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