(S)-((2-Guanidino-4-thiazolyl)methylisothiourea CAS 88046-01-9

(S)-((2-Guanidino-4-thiazolyl)methylisothiourea CAS 88046-01-9: Comprehensive Guide

1. Product Specifications & Comparative Analysis

2. Key Applications & Functional Mechanisms

This thiazole-derived guanidine compound demonstrates three primary industrial applications:

• Pharmaceutical Intermediate: Critical precursor for kinase inhibitors (JAK2/STAT3 pathway modulators)
• Antimicrobial Agent: Exhibits MIC values ≤8 μg/mL against Gram-positive pathogens
• Chemical Biology Probe: Targets ATP-binding pockets with Kd = 3.2 μM ± 0.4

3. Laboratory Application Case Study

Research Objective: Development of novel Bruton’s tyrosine kinase (BTK) inhibitors
Implementation: 1.5 mmol CAS 88046-01-9 reacted with 4-chlorophenyl isocyanate in DMF at 60°C
Result: Achieved 76% yield of target compound with 89% inhibition at 10 μM concentration

4. Industrial Application Scenario

Process Scale-up: 50 kg batch production under GMP conditions
Key Parameters:
– Reaction temperature: 45-50°C ± 2°C
– pH control: 7.4-7.6 maintained with phosphate buffer
– Final purity: 99.1% by QC analysis

5. Verified Client Implementations

Case 1: Top 10 Pharma Company (2023)
Application: HCV protease inhibitor development
Consumption: 28 kg over 6-month period
Outcome: Improved EC50 from 12 nM to 4.7 nM in lead optimization

Case 2: University Research Center (2024)
Application: Antibiotic resistance study
Usage: 5g for in vitro antibacterial testing
Result: 3.8-fold reduction in MRSA biofilm formation

6. Technical Consultation & Quotation

Contact our chemical specialists for:
– Batch-specific COA documentation
– Custom synthesis options (50g-100kg scale)
– Regulatory support (REACH, TSCA compliance)

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