D-Proline CAS 344-25-2: Comprehensive User Guide

1. Product Overview & Specifications

D-Proline (CAS 344-25-2) is a non-proteinogenic amino acid with the molecular formula C₅H₉NO₂. As the D-enantiomer of proline, it serves as a critical chiral building block in asymmetric synthesis.

2. Key Applications

D-Proline demonstrates exceptional utility in:

• Asymmetric organocatalysis
• Peptide synthesis (particularly for β-turn induction)
• Pharmaceutical intermediates for:
  • Antiviral drugs
  • ACE inhibitors
  • Neurological agents
• Chiral resolution agent in HPLC columns

3. Usage Scenarios

Scenario 1: Catalytic Asymmetric Aldol Reaction

Optimal Conditions:
– Concentration: 20 mol% in DMSO
– Temperature: 4°C
– Reaction Time: 24-48 hrs
Achieves >90% ee in tested substrates

Scenario 2: Peptide Modification

When incorporated at position 2 in pentapeptides:
– Increases β-sheet stability by 40%
– Enhances protease resistance by 3-fold

4. Client Case Studies

Case 1: Top 10 Pharma Company (Confidential)

Challenge: Required high-purity D-Proline for scale-up of Phase III antiviral candidate
Solution:
– Custom 99.5% purity grade
– 200kg delivery within 3 weeks
Outcome: Enabled 92% yield in final coupling step

Case 2: University Research Team

Project: Development of chiral MOFs
Usage: 50g batches for crystal engineering
Result: Achieved record 98% enantioselectivity in gas separation

5. Request Quotation

Our GMP-certified facility produces D-Proline meeting:

• USP/EP standards
• ISO 9001:2015 certified
• Custom synthesis available

Contact our technical team:
Email: info@vivalr.com
Tel: (86) 15866781826