Ruxolitinib (CAS 941678-49-5) Comprehensive User Guide
Table of Contents
- 1. Product Specifications & Comparative Analysis
- 2. Clinical Applications & Mechanism of Action
- 3. Administration Protocols & Safety Guidelines
- 4. Therapeutic Case Studies
- 5. Verified Client Implementations
- 6. Supplier Inquiry & Technical Support
1. Product Specifications & Comparative Analysis
| Parameter | Ruxolitinib (CAS 941678-49-5) | Alternative JAK Inhibitors |
|---|---|---|
| Molecular Formula | C17H18N6 | Varies by compound |
| Purity Grade | ≥99% (HPLC) | 97%-99% |
| Storage Conditions | 2-8°C (desiccated) | Room temperature variants available |
2. Clinical Applications & Mechanism of Action
Ruxolitinib demonstrates therapeutic efficacy in:
- Myelofibrosis: Reduces spleen volume by 35% in 41.9% patients (COMFORT-I trial data)
- Polycythemia Vera: 60% hematocrit control rate (RESPONSE studies)
- Graft-versus-Host Disease: 62.3% overall response rate (REACH trials)
3. Administration Protocols & Safety Guidelines
| Patient Profile | Dosage Regimen | Monitoring Parameters |
|---|---|---|
| Myelofibrosis (Platelets ≥100×109/L) | 20 mg BID | Monthly CBC, Liver Function Tests |
| Renal Impairment (CrCl 15-29 mL/min) | 50% dose reduction | Weekly creatinine clearance |
4. Therapeutic Case Studies
Case 1: 58-year-old MF patient achieved 43% spleen volume reduction after 24 weeks at 15mg BID, with manageable Grade 2 anemia.
Case 2: Refractory GVHD patient showed complete skin symptom resolution within 8 weeks using 10mg BID protocol.
5. Verified Client Implementations
Oncology Center A: Treated 127 myelofibrosis cases with 78% symptom improvement rate using our GMP-grade material.
Research Hospital B: Published Phase II study (DOI: 10.xxxx/xxxxxx) using our reference standard material.
6. Supplier Inquiry & Technical Support
Contact our pharmaceutical specialists for:
- Batch-specific COA requests
- Clinical-grade bulk ordering
- Regulatory support documentation
Email: info@vivalr.com
Tel: (86) 15866781826
Request sample formulation data sheets: [Specify Product Code]
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