4-(HYDROXYMETHYL)PHENYLACETIC ACID (CAS 73401-74-8) Ultimate Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 4-(Hydroxymethyl)phenylacetic Acid |
| CAS Number | 73401-74-8 |
| Molecular Formula | C9H10O3 |
| Molecular Weight | 166.18 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥98% (HPLC) |
| Melting Point | 142-145°C |
| Storage | 2-8°C in dry environment |
2. Key Applications & Industry Uses
Pharmaceutical Intermediates
Critical component in synthesis of NSAIDs and tyrosine kinase inhibitors
Organic Synthesis
Building block for chiral compounds in asymmetric catalysis
Bioconjugation
Cross-linking agent for antibody-drug conjugates (ADCs)
3. Technical Comparison with Alternatives
| Feature | 4-HMPAA | Phenylacetic Acid | 4-Hydroxybenzoic Acid |
|---|---|---|---|
| Water Solubility | Moderate | Low | High |
| Thermal Stability | Excellent | Good | Poor |
| Reactivity | Dual functional groups | Single active site | Limited reactivity |
4. Operational Guidelines & Safety
Handling Requirements
Use NIOSH-approved respirator when handling powder form
Storage Protocol
Maintain inert atmosphere for long-term storage >6 months
5. Real-World Application Cases
Case 1: Oncology Drug Development
Client: Top 10 Pharma Company
Usage: HER2 inhibitor intermediate synthesis
Result: 22% yield improvement vs previous synthesis route
Case 2: Advanced Material Research
Client: European Research Institute
Usage: Conductive polymer side chain modification
Result: Achieved 15.3% conductivity enhancement
6. Procurement & Custom Solutions
Available in R&D to bulk quantities (1g – 100kg)
Custom synthesis and derivatization services
Technical support: info@vivalr.com
Direct inquiry: (86) 15866781826
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