3-Hydroxybenzaldehyde (CAS 100-83-4): Comprehensive Product Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification | Comparison with Analogues |
|---|---|---|
| Chemical Name | 3-Hydroxybenzaldehyde (m-Hydroxybenzaldehyde) |
Distinct hydroxyl positioning vs. o-/p-isomers |
| CAS No. | 100-83-4 | Unique identifier per IUPAC |
| Molecular Formula | C7H6O2 | Same as benzaldehyde derivatives |
| Molecular Weight | 122.12 g/mol | Lower than brominated derivatives |
| Appearance | Colorless to pale yellow crystals | Similar to phenolic aldehydes |
| Melting Point | 102-105°C | Higher than vanillin (80-81°C) |
| Boiling Point | 191°C at 50 mmHg | Lower volatility than benzaldehyde |
| Solubility | Sparingly in water Miscible with ethanol, acetone, ether |
Better organic solubility than salicylaldehyde |
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates
Core component in synthesis of:
- Roxatidine acetate hydrochloride (anti-ulcer agent)
- Schiff base pharmaceuticals
- Antimicrobial drug precursors
Specialty Chemicals
- Photoemulsion additives for silver halide photography
- High-performance dye intermediates
- Polymer modification agents
Analytical Chemistry
- Chromogenic agent in Schiff’s reagent formulations
- Metal ion chelation studies
3. Manufacturing Process Comparison
| Process | Traditional Method | Advanced Synthesis |
|---|---|---|
| Starting Material | m-Nitrobenzaldehyde | m-Cresol derivatives |
| Key Steps | 1. Bisulfite addition 2. Iron reduction 3. Diazotization |
Catalytic hydroxylation Oxidative coupling |
| Yield | 68-72% | 82-85% |
| Environmental Impact | High wastewater generation (COD >5,000 mg/L) |
Closed-loop solvent recovery (COD <800 mg/L) |
| Purity | 97-98% | 99.5%+ |
4. Safety & Handling Guidelines
Hazard Classification
- Xi – Irritant (R36/37/38)
- WGK 3 – Water hazard class
Protective Measures
- PPE: Nitrile gloves, chemical goggles
- Ventilation: Local exhaust required
- Storage: Amber glass in cool (<25°C), dry conditions
Emergency Protocols
- Eye contact: Flush with saline ≥15 minutes
- Skin exposure: Wash with 5% sodium bicarbonate
- Spill management: Absorb with vermiculite
5. Industry Implementation Cases
Case 1: Pharmaceutical Synthesis
Client: EU-based API manufacturer
Application: Roxatidine intermediate scale-up
Result: Achieved 92% yield through optimized diazotization at 5°C
Case 2: Agrochemical Production
Client: Asian crop protection company
Application: Fungicide synergist development
Result: Enhanced bioactivity by 40% vs. o-isomer
Case 3: Advanced Materials
Client: US polymer research institute
Application: Epoxy resin modification
Result: Improved thermal stability (Tg +18°C)
6. Technical Inquiry & Ordering
For product specifications, MSDS, or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826
Technical support available for formulation optimization and custom synthesis.
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