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Glycofurol (CAS 9004-76-6/31692-85-0): Comprehensive Product Guide 2025
Table of Contents
- Product Overview & Specifications
- Parameter Comparison with Similar Solvents
- Detailed Applications & Use Cases
- Real-World Case Studies
- Procurement Guide for Industrial Buyers
- Request Sample or Quotation
Product Overview & Specifications
Glycofurol (CAS 9004-76-6/31692-85-0), also known as Tetraglycol or Polyethylene Glycol Monomethyl Ether, is a water-miscible solvent widely used in pharmaceuticals, cosmetics, and industrial applications.
| Parameter | Specification |
|---|---|
| Molecular Formula | C3H6O(C2H4O)n (n=3-4) |
| Molecular Weight | 194.23 g/mol (n=3) |
| Appearance | Colorless viscous liquid |
| Solubility | Miscible with water, ethanol, acetone |
| Purity | ≥99.5% (Pharmaceutical Grade) |
| Storage | 2-8°C in airtight containers |
Parameter Comparison with Similar Solvents
| Property | Glycofurol | PEG 400 | Ethanol | Glycerol |
|---|---|---|---|---|
| Polarity | Medium | High | High | Very High |
| Boiling Point (°C) | 245-260 | >250 | 78 | 290 |
| Acute Toxicity (LD50) | >5000 mg/kg | >5000 mg/kg | 7060 mg/kg | >6000 mg/kg |
| Pharmaceutical Compatibility | Excellent | Good | Limited | Moderate |
Detailed Applications & Use Cases
1. Drug Delivery Systems
Glycofurol enhances solubility of poorly water-soluble APIs in injectable formulations, particularly for:
- Paclitaxel nanoparticle suspensions
- Hormone replacement therapies
- Antiviral drug formulations
2. Vaccine Adjuvants
Used in combination with squalene-based emulsions to improve antigen stability and immune response.
3. Cosmetic Formulations
- Carrier for retinoids in anti-aging creams
- Humectant in moisturizing serums
- Solvent for UV filters in sunscreens
Real-World Case Studies
Case Study 1: Oncology Drug Development
Client: Top 10 Global Pharma Company
Challenge: Stabilize cabazitaxel injectable formulation
Solution: 15% Glycofurol + Vitamin E TPGS system
Result: 18-month shelf life at 25°C with <2% degradation
Case Study 2: mRNA Vaccine Production
Client: European Biotech Startup
Challenge: Prevent lipid nanoparticle aggregation
Solution: Glycofurol-based cryoprotectant mixture
Result: 98% particle integrity after 6 freeze-thaw cycles
Procurement Guide for Industrial Buyers
- Grade Selection:
- Pharmaceutical Grade (USP/EP compliance)
- Industrial Grade (for non-GMP applications)
- Supplier Evaluation:
- ISO 9001/14001 certification
- FDA Drug Master File availability
- Batch Testing:
- Require residual ethylene oxide analysis
- Verify peroxide content <0.02%
Request Sample or Quotation
For technical specifications, bulk pricing, or formulation support:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Request our 2025 Glycofurol Application Handbook containing 30+ validated formulation protocols.
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