Methyl-β-Cyclodextrin (CAS 128446-36-6) Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Basic Parameters
| Parameter | Value |
|---|---|
| CAS Number | 128446-36-6 |
| Molecular Formula | C54H94O35 |
| Molecular Weight | 1303.3–1331.4 g/mol* |
| Appearance | White to off-white crystalline powder |
| Melting Point | 180–182°C |
| Water Solubility | ≥50 mg/mL (25°C) |
| Storage | -20°C (long-term), 4°C (short-term) |
*Variations depend on methylation degree (average Mn: ~1310)
Comparative Analysis
| Feature | Methyl-β-Cyclodextrin | Standard β-Cyclodextrin |
|---|---|---|
| Hydrophobicity | Enhanced | Moderate |
| Solubility Enhancement | Superior for lipophilic compounds | Limited |
| Biomedical Applications | Cholesterol depletion, drug delivery | Basic encapsulation |
| Regulatory Status | Pharmaceutical-grade available | Food-grade common |
2. Key Applications & Industrial Uses
Pharmaceutical Industry
- Drug solubility enhancement for oral/injectable formulations
- Cholesterol modulation in cell biology research (IC50: 3.33–4.23 mM)
- Targeted drug delivery systems
Food & Cosmetic Technology
- Flavor encapsulation in functional foods
- Stabilization of volatile fragrances
- Active ingredient protection against oxidation
Advanced Research
- Membrane protein studies
- Nanoparticle functionalization
- Diagnostic reagent stabilization
3. Functional Advantages & Technical Insights
Mechanism of Action
The cyclic heptasaccharide structure creates a hydrophobic cavity (7.8Å diameter) capable of forming inclusion complexes with:
- Drug molecules (e.g., antimycotics, steroids)
- Fatty acids & vitamins
- Organic pollutants (environmental applications)
Performance Metrics
- Complexation efficiency: 85–92% for typical APIs
- Thermal stability: Decomposition >250°C
- pH tolerance: Stable across 3–10 pH range
4. Real-World Case Studies
Case 1: Pharmaceutical Formulation Optimization
Client: Leading Chinese API Manufacturer
Challenge: Improve bioavailability of a BCS Class II drug (aqueous solubility <0.1 mg/mL)
Solution: 1:2 drug:cyclodextrin complexation
Result: 12x solubility increase, 80% oral bioavailability achieved
Case 2: Cosmetic Active Stabilization
Client: International Skincare Brand
Challenge: Prevent retinol degradation in anti-aging serum
Solution: 5% w/w Methyl-β-CD encapsulation
Result: 6-month stability at 40°C/75% RH (vs 2 weeks baseline)
5. Technical Support & Inquiry
Our technical team provides:
- Custom complexation studies
- Regulatory documentation support
- Bulk manufacturing (GMP options available)
Contact our experts:
Email: info@vivalr.com
Tel: (86) 15866781826



评论
目前还没有评论。