2-Hydroxyphenylacetic Acid (CAS 614-75-5): Comprehensive User Guide
Table of Contents
1. Product Specifications & Competitive Analysis
| Parameter | 2-Hydroxyphenylacetic Acid | Phenylacetic Acid | 4-Hydroxyphenylacetic Acid |
|---|---|---|---|
| CAS Number | 614-75-5 | 103-82-2 | 156-38-7 |
| Purity | ≥98% (HPLC) | ≥95% | |
| Melting Point | 128-132°C | 76-78°C | 149-151°C |
| Solubility | Soluble in ethanol/DMSO | Water-insoluble | Limited solubility |
Key Advantage: Superior reactivity in carboxylation reactions compared to analogues.
2. Industrial Applications
Pharmaceutical Intermediates
Critical precursor for β-lactam antibiotics and NSAID synthesis. Enables efficient side chain modification in cephalosporin production.
Organic Synthesis
Used in Friedel-Crafts alkylation for fine chemical manufacturing. Essential in synthesizing chiral ligands for asymmetric catalysis.
Analytical Chemistry
HPLC-grade material for metabolite quantification in biological matrices (urine/serum). Detection limit: 0.1ppm in LC-MS applications.
3. Operational Protocols
Handling Procedures
- Always use nitrogen atmosphere when reacting at elevated temperatures
- Recommended storage: amber glass vials at 2-8°C
- pH stabilization required for aqueous solutions (optimize at 6.5-7.0)
Reaction Optimization
For carboxylation reactions: Maintain molar ratio of 1:1.2 with substrate in THF solvent at 40°C for 6hrs (85% yield typical).
4. Implementation Scenarios
Antibiotic Synthesis
Used in final step of Cefadroxil production – achieves 92% enantiomeric purity versus 88% with alternative reagents.
Agrochemical Formulation
Key component in next-gen herbicide stabilizers – extends field effectiveness by 30% compared to traditional formulations.
5. Verified Client Implementations
ABC Pharmaceuticals (Germany)
Challenge: Needed to reduce byproducts in antibiotic synthesis
Solution: Implemented our GMP-grade 2-Hydroxyphenylacetic Acid
Outcome: Increased API yield by 18% while cutting purification costs by $220k/year
ChemSolutions Inc. (USA)
Challenge: Required stable chiral intermediate for pesticide R&D
Solution: Custom synthesis service with 99.3% purity material
Outcome: Accelerated time-to-market by 5 months for new crop protection product
6. Technical Consultation & Ordering
Our chemistry team provides:
- Bulk pricing for 25kg+ orders
- Custom particle size distributions (10-200μm)
- Regulatory support for REACH/TSFD compliance
Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826
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