4-Fluorobenzoic Acid CAS 456-22-4
Appearance: White crystalline powder
Assay: ≥99%
Packing: 25kg/fiber drum
Capacity: 1000mt/year
Sample: Available
related documents:
COA of 4-Fluorobenzoic Acid CAS 456-22-4
TDS of 4-Fluorobenzoic Acid CAS 456-22-4
SDS of 4-Fluorobenzoic Acid CAS 456-22-4
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Product Overview: 4-Fluorobenzoic Acid (CAS 456-22-4)
Table of Contents
1. Basic Parameters & Comparative Analysis
| Parameter | Specification | Grade Comparison |
|---|---|---|
| CAS Number | 456-22-4 | Consistent across industrial/reagent grades |
| Molecular Formula | C7H5FO2 | Same structural configuration |
| Molecular Weight | 140.11 g/mol | ±0.02 tolerance |
| Purity | 98-99.5% | Industrial (98%) vs. Research (≥99%) |
| Melting Point | 182-184°C | Consistent thermal properties |
| Flash Point | 107.2°C | Standard flammability class |
2. Applications & Industrial Uses
Core Functional Roles:
- Pharmaceutical Intermediate: Key precursor for anticonvulsant agents (e.g., Carabersat development)
- Agrochemical Production: Building block for advanced fungicides
- Material Science: Fluorinated polymer modification
- Research Chemistry: Isotope-labeled compound synthesis
3. Operational Guidelines & Safety Protocols
Handling Requirements:
- PPE: Chemical-resistant gloves + vapor respirator
- Storage: Airtight containers @ RT, RH ≤40%
- Incompatibilities: Strong oxidizers, alkaline metals
Emergency Response:
- Spill Management: Absorb with inert material, avoid aqueous runoff
- Fire Suppression: Alcohol-resistant foam ONLY
4. Case Studies in Pharmaceutical Synthesis
Radiolabeled Compound Production:
- Objective: 14C-labeled SB-204269 development
- Process:
- Cyanation of 4-iodofluorobenzene
- Alkaline hydrolysis to [14C]-4-fluorobenzoic acid
- EDC-mediated coupling with benzopyran derivative
- Yield Optimization: 78% purity through recrystallization
5. Client Success Stories
Case 1: Agrochemical Manufacturer
- Client: Top 5 Chinese pesticide formulator
- Challenge: Scaling fluorinated fungicide production
- Solution: Bulk supply @ 500kg/mo, purity consistency 99±0.3%
- Outcome: 22% production cost reduction
Case 2: Research Institute
- Client: EU pharmaceutical R&D center
- Requirement: GMP-grade material for clinical trial compounds
- Delivery: 99.5% purity, ICH-compliant documentation
- Impact: Accelerated regulatory approval by 14 weeks
6. Contact for Technical Consultation
Request custom synthesis protocols or bulk pricing:
- Email: info@vivalr.com
- Tel: (86) 15866781826 (24/7 technical support)
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