Dimethyl Sulfate (CAS 77-78-1) User Guide
Table of Contents
- Product Information & Specifications
- Detailed Applications
- Operational Guidelines
- Industry Use Cases
- Client Success Stories
- Contact for Technical Consultation
Product Information & Specifications
| Parameter | Dimethyl Sulfate | Diethyl Sulfate | Methyl Iodide |
|---|---|---|---|
| CAS Number | 77-78-1 | 64-67-5 | 74-88-4 |
| Molecular Formula | C2H6O4S | C4H10O4S | CH3I |
| Boiling Point | 188°C (dec) | 209°C | 42°C |
| Reactivity | High methylating agent | Moderate ethylating agent | Rapid alkylation |
| Toxicity | Extremely toxic (T+) | Harmful (Xn) | Toxic (T) |
Detailed Applications
Primary Industrial Uses:
- Methylation agent in pharmaceutical intermediates
- Dye manufacturing catalyst
- Quaternary ammonium compound production
- Surface treatment chemicals
- Laboratory-scale organic synthesis
Operational Guidelines
Critical Safety Protocols:
- Use NIOSH-approved respirators with organic vapor cartridges
- Maintain operating temperatures below 40°C
- Implement secondary containment for storage vessels
- Neutralize spills with 10% ammonia solution immediately
Industry Use Cases
Pharmaceutical Application:
Production of antihistamine APIs through O-methylation reactions, achieving 92% yield improvement over traditional methods.
Agrochemical Implementation:
Synthesis of pyrethroid insecticides with 40% reduced reaction time compared to ethylating alternatives.
Client Success Stories
Case 1: European Pharma Innovator
Challenge: Required high-purity methylated intermediates for antiviral drug development
Solution: Optimized dimethyl sulfate stoichiometry in nucleoside methylation
Outcome: Achieved 99.8% purity with 30% cost reduction
Case 2: Asian Dye Manufacturer
Challenge: Inconsistent color fastness in textile dyes
Solution: Implemented controlled dimethyl sulfate methylation process
Outcome: Produced wash-fast dyes meeting REACH compliance standards
Technical Consultation & Ordering
For material safety data sheets or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826
Our chemical engineering team provides:
- Custom concentration formulations
- Reaction optimization studies
- Closed-system handling solutions



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