Table of Contents
- Croscarmellose Sodium Overview
- Technical Specifications & Comparative Analysis
- Pharmaceutical Applications & Mechanisms
- Formulation Guidelines & Best Practices
- Industry Implementation Case Studies
- Technical Consultation & Sample Requests
Croscarmellose Sodium (CAS 74811-65-7) Overview
Key Characteristics
| Parameter | Specification |
|---|---|
| Chemical Name | Sodium salt of cross-linked carboxymethylcellulose |
| Appearance | White or off-white free-flowing powder |
| pH (1% solution) | 5.0-7.0 |
| Swelling Capacity | ≥50 ml/10min |
Technical Specifications & Grade Comparison
| Grade | Particle Size (μm) | Moisture Content | Viscosity (mPa·s) |
|---|---|---|---|
| Pharmaceutical Grade | 50-150 | ≤5% | 10-30 |
| Industrial Grade | 150-300 | ≤7% | 30-50 |
Pharmaceutical Formulation Applications
Primary Functions
- Tablet disintegrant in immediate-release formulations
- Dissolution rate enhancer for poorly soluble APIs
- Wetting agent in dry granulation processes
Optimal Usage Parameters
| Formulation Type | Recommended Concentration | Processing Method |
|---|---|---|
| Direct Compression | 2-5% w/w | Dry blending |
| Wet Granulation | 1-3% extragranular | Post-granulation addition |
Industry Implementation Case Studies
Case 1: Novo Pharmaceuticals
Challenge: Improve disintegration time of high-dose ibuprofen tablets
Solution: 4% Croscarmellose Sodium in extragranular phase
Result: Disintegration time reduced from 12min to 2.5min
Case 2: Geneva Pharma
Challenge: Prevent capping in vitamin B complex tablets
Solution: 3% Croscarmellose Sodium with modified drying cycle
Result: Tablet hardness increased by 40% with zero capping
Technical Consultation & Ordering Information
Contact our formulation specialists:
Email: info@vivalr.com
Phone: (86) 15866781826
相关产品
Chemical Name: Eicosatetraynoic acid(ETYA)
Cas No.: 1191-85-1
Molecular Fomula: C20H24O2
Molecular Weight: 296.4
Chemical Name: Dehydrocholic acid
Synonyms: Acide dehydrocholique; Triketocholanic acid
CAS No.: 81-23-2
Molecular Formula: C24H34O5
Molecular Weight: 402.53
Appearance: Powder
Chemical Name: Choline salicylate
CAS No.: 2016-36-6
Molecular Formula: C12H19NO4
Molecular Weight: 241.28
Appearance: Red-Brown Crystal
Chemical Name: alpha-Hexylcinnamaldehyde
CAS No.: 101-86-0
Molecular Formula: C15H20O
Molecular Weight: 216.32
Appearance: Yellow Liquid
Chemical Name: 1,1,2,2-Tetrachloroethane
Other Name: Tetrachlorethane
CAS No.: 79-34-5
Molecular Formula: C2H2Cl4
Molecular Weight: 167.85
Appearance: Liquid
Chemical Name: D-Phenothrin
CAS No.: 26046-85-5
Molecular Formula: C23H26O3
Molecular Weight: 350.45
Appearance: Oil
Chemical Name: 3-Hydroxybutyric acid
CAS No.: 625-71-8
Molecular Formula: C4H8O3
Molecular Weight: 104.1
Appearance: White powder
Chemical Name: Tribehenin
Cas No.: 18641-57-1
Molecular Fomula: C69H134O6
Molecular Weight: 1059.8
Appearance: White waxy powder or solid
Chemical Name: D-PANTOTHENIC ACID
CAS No.: 79-83-4
Molecular Formula: C9H17NO5
Molecular Weight: 219.24
Appearance: Colorless or Light Yellow Oily Liquid
Chemical Name: Isoflavone
Synonyms: Soy Isoflavone; Soybean Lsoflavones; 3-Phenylchromen-4-one; 3-Phenylchromone
CAS No.: 574-12-9
Molecular Formula: C15H10O2
Molecular Weight: 222.24
Appearance: Powder
Chemical Name: Di-n-amyl disulfide
Cas No.: 112-51-6
Molecular Fomula: C10H22S2
Molecular Weight: 206.41
Chemical Name: DL-4-Chlorophenylglycine
Cas No.: 6212-33-5
Molecular Fomula: C8H8ClNO2
Molecular Weight: 185.61
评论
目前还没有评论。