2,4-difluorothiophenol cas 1996-44-7

2,4-Difluorothiophenol (CAS 1996-44-7): Technical Guide & Applications

Table of Contents

• 1. Product Overview & Specifications
• 2. Key Applications & Use Cases
• 3. Industry Case Studies
• 4. Operational Guidelines
• 5. Supplier Comparison
• 6. Contact for Quotation

1. Product Overview & Specifications

CAS No.: 1996-44-7
Molecular Formula: C6H4F2S
Molecular Weight: 146.16 g/mol
Appearance: Clear colorless to pale yellow liquid
Purity: ≥98% (GC analysis)
Boiling Point: 165-167°C
Density: 1.362 g/cm³ at 25°C

Comparative Analysis with Analogues

2. Key Applications & Use Cases

2.1 Pharmaceutical Intermediates

Used in synthesizing fluorinated arylthioethers for kinase inhibitors (e.g., EGFR inhibitors in oncology).

2.2 Agrochemicals

Key precursor for sulfonylurea herbicides and fungicides with enhanced leaf permeability.

2.3 Polymer Chemistry

Crosslinking agent in fluoropolymer production, improving thermal stability up to 300°C.

3. Industry Case Studies

Case 1: PharmaCorp Inc. (2023)

Challenge: Develop a third-generation EGFR inhibitor with reduced off-target effects.
Solution: Integrated 2,4-difluorothiophenol to create a meta-fluorinated thioether linkage.
Result: 40% improved selectivity vs. wild-type EGFR in preclinical models.

Case 2: AgroGrowth Ltd. (2024)

Challenge: Control resistant strains of Puccinia triticina in wheat crops.
Solution: Formulated a thiophenol-derived triazole fungicide.
Result: 92% disease suppression at 50 ppm concentration.

4. Operational Guidelines

4.1 Storage

Store under N₂ at 2-8°C in amber glass bottles. Shelf life: 24 months unopened.

4.2 Handling

Use PTFE-lined equipment due to sulfur reactivity with metals. Mandatory PPE: neoprene gloves, face shield.

5. Supplier Comparison

6. Request Custom Quote

Email: info@vivalr.com
Tel: (86) 15866781826
Provide: Required quantity, purity grade, and SDS/GMP needs.