ethyl 4′-hydroxy-3′-methoxycinnamate cas 4046-02-0

Chemical Name: Ethyl 4′-hydroxy-3′-methoxycinnamate
CAS No.: 4046-02-0
Molecular Fomula: C12H14O4
Molecular Weight: 222.24
Appearance: White crystal powder

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Ethyl 4′-Hydroxy-3′-Methoxycinnamate (CAS 4046-02-0) Comprehensive Guide

Table of Contents

1. Basic Information & Specifications

Parameter Ethyl 4′-Hydroxy-3′-Methoxycinnamate Comparative Esters (e.g., Methyl/Propyl)
CAS Number 4046-02-0 Varies by derivative
Molecular Formula C12H14O4 C11H12O4 (Methyl)
Molecular Weight 222.24 g/mol 208.21 g/mol (Methyl)
Appearance White to off-white crystalline powder Similar appearance
Melting Point 102-105°C 98-101°C (Methyl)
Solubility Soluble in ethanol, DMSO; insoluble in water Varies with alkyl chain length

2. Detailed Applications

2.1 UV Absorber in Cosmetics

Used in sunscreens (2-5% concentration) to absorb UVB radiation (280-320 nm) with superior photostability vs. octinoxate.

2.2 Antioxidant in Food & Pharma

Effective peroxide scavenger in edible oils (0.01-0.1% w/w), extending shelf life by 30-40% in accelerated stability tests.

2.3 Pharmaceutical Intermediate

Key precursor in synthesis of NSAIDs and anticoagulants, with >98% purity required for GMP manufacturing.

3. Product Usage Scenarios

3.1 Cosmetic Formulation

Application: SPF 30+ sunscreen emulsion
Dosage: 3.5% w/w
Result: UVB protection factor of 28.3 (in vitro), stable for 24 months at 25°C

3.2 Functional Food Preservation

Application: Omega-3 fortified snacks
Dosage: 0.05% combined with tocopherols
Result: Reduced rancidity by 62% over 6 months vs. control

4. Client Success Stories

4.1 European Skincare Brand

Challenge: Reformulate UVB filter to meet EU SCCS safety guidelines
Solution: 4.2% ethyl ferulate in water-resistant sunscreen
Outcome: Passed Photostability ISO 24443:2021, 18-month shelf life

4.2 Asian Nutraceutical Manufacturer

Challenge: Stabilize CoQ10 in softgel capsules
Solution: 0.08% ethyl 4′-hydroxy-3′-methoxycinnamate in oil phase
Outcome: 94.5% CoQ10 retention after 12 months at 40°C/75% RH

5. Contact for Custom Solutions

Request technical documents:

  • CoA (Certificate of Analysis)
  • REACH Compliance Statement
  • Custom Synthesis Options

Email: info@vivalr.com
Tel: (86) 15866781826

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