Ethyl 4′-Hydroxy-3′-Methoxycinnamate (CAS 4046-02-0) Comprehensive Guide
Table of Contents
- Basic Information & Specifications
- Detailed Applications
- Product Usage Scenarios
- Client Success Stories
- Contact for Custom Solutions
1. Basic Information & Specifications
| Parameter | Ethyl 4′-Hydroxy-3′-Methoxycinnamate | Comparative Esters (e.g., Methyl/Propyl) |
|---|---|---|
| CAS Number | 4046-02-0 | Varies by derivative |
| Molecular Formula | C12H14O4 | C11H12O4 (Methyl) |
| Molecular Weight | 222.24 g/mol | 208.21 g/mol (Methyl) |
| Appearance | White to off-white crystalline powder | Similar appearance |
| Melting Point | 102-105°C | 98-101°C (Methyl) |
| Solubility | Soluble in ethanol, DMSO; insoluble in water | Varies with alkyl chain length |
2. Detailed Applications
2.1 UV Absorber in Cosmetics
Used in sunscreens (2-5% concentration) to absorb UVB radiation (280-320 nm) with superior photostability vs. octinoxate.
2.2 Antioxidant in Food & Pharma
Effective peroxide scavenger in edible oils (0.01-0.1% w/w), extending shelf life by 30-40% in accelerated stability tests.
2.3 Pharmaceutical Intermediate
Key precursor in synthesis of NSAIDs and anticoagulants, with >98% purity required for GMP manufacturing.
3. Product Usage Scenarios
3.1 Cosmetic Formulation
Application: SPF 30+ sunscreen emulsion
Dosage: 3.5% w/w
Result: UVB protection factor of 28.3 (in vitro), stable for 24 months at 25°C
3.2 Functional Food Preservation
Application: Omega-3 fortified snacks
Dosage: 0.05% combined with tocopherols
Result: Reduced rancidity by 62% over 6 months vs. control
4. Client Success Stories
4.1 European Skincare Brand
Challenge: Reformulate UVB filter to meet EU SCCS safety guidelines
Solution: 4.2% ethyl ferulate in water-resistant sunscreen
Outcome: Passed Photostability ISO 24443:2021, 18-month shelf life
4.2 Asian Nutraceutical Manufacturer
Challenge: Stabilize CoQ10 in softgel capsules
Solution: 0.08% ethyl 4′-hydroxy-3′-methoxycinnamate in oil phase
Outcome: 94.5% CoQ10 retention after 12 months at 40°C/75% RH
5. Contact for Custom Solutions
Request technical documents:
- CoA (Certificate of Analysis)
- REACH Compliance Statement
- Custom Synthesis Options
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