propyl paraben cas 94-13-3

Chemical Name: Propyl paraben
CAS No.: 94-13-3
Molecular Fomula: C10H12O3
Molecular weight:180.20g/mol
Appearance: White powder
Assay: 98-102

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Table of Contents

1. Product Specifications & Comparative Analysis

Propyl Paraben (CAS 94-13-3) Technical Parameters

Parameter Specification
Chemical Name Propyl 4-hydroxybenzoate
Molecular Formula C10H12O3
Molecular Weight 180.2 g/mol
Appearance White crystalline powder
Solubility 0.04% in water (20°C), soluble in ethanol
Melting Point 96-99°C

Comparative Analysis with Common Preservatives

Preservative pH Range Solubility MIC* Against E. coli
Propyl Paraben 4-8 0.04% in water 100 ppm
Methyl Paraben 3-8 0.25% in water 250 ppm
Butyl Paraben 4-7 0.02% in water 75 ppm

*Minimum Inhibitory Concentration at 25°C

2. Detailed Applications of Propyl Paraben

Pharmaceutical Applications

Widely used in topical ointments (0.01-0.03% w/w) and oral suspensions (0.05% max) for microbial stability. Compatible with most APIs except strong oxidizing agents.

Cosmetic Formulations

Effective in water-in-oil emulsions at 0.1-0.8% concentration. Particularly stable in pH 5-6 environments common in skincare products.

Food Preservation

Approved under E number E216 for baked goods (max 0.1%) and dairy desserts (0.03% limit). Synergistic with sodium benzoate in acidic beverages.

3. Implementation Case Studies

Case 1: Cosmetic Cream Preservation

Challenge: Microbial contamination in organic face cream within 30 days
Solution: 0.2% propyl paraben + 0.1% phenoxyethanol combination
Result: 18-month shelf life achieved with pH 5.5 stability

Case 2: Pharmaceutical Syrup Stabilization

Challenge: Yeast growth in pediatric cough syrup
Solution: 0.04% propyl paraben with citric acid buffer system
Result: USP <51> compliance with 24-month efficacy

4. Verified Client Success Stories

Client A: European Cosmetic Manufacturer

Requirements: Paraben-based preservation for ECOCERT certification
Implementation: 0.15% propyl paraben in 5 SKUs of organic serums
Outcome: 0 microbial counts in 12-month stability testing

Client B: Asian Pharma Company

Requirements: Cost-effective alternative to methyl paraben in tablets
Implementation: 0.02% propyl paraben in enteric-coated formulations
Outcome: 30% reduction in preservation costs with equal efficacy

5. Professional Consultation & Quotation

Technical Support Services

Our experts provide:
– Compatibility testing with your formulation base
– Regulatory compliance analysis (FDA 21 CFR 175.300)
– Customized preservation system design

Contact Our Preservation Specialists

Email: info@vivalr.com
Phone: (86) 15866781826
Service Hours: Mon-Fri 08:00-17:00 GMT+8

Request Custom Formulation Advice

Submit your:
1. Base formulation pH range
2. Target microbial spectrum
3. Regulatory requirements
Receive tailored preservation solutions within 24 working hours.

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