trimethylacetic anhydride cas 1538-75-6

Chemical Name: Trimethylacetic anhydride
CAS No.:1538-75-6
Molecular Fomula: C10H18O3
Molecular weight: 186.25
Appearance: Colorlesstransparentliquid
Assay:99.0%min
 
related documents:

COA of trimethylacetic anhydride
TDS of trimethylacetic anhydride

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Trimethylacetic Anhydride (CAS 1538-75-6) Comprehensive Guide

Table of Contents

Product Overview & Specifications

Parameter Value
CAS Number 1538-75-6
Molecular Formula C10H18O3
Molecular Weight 186.25 g/mol
Boiling Point 193°C (lit.)
Density 0.918 g/mL at 25°C
Refractive Index n20/D: 1.409
Flash Point 57.2°C (135°F)
Solubility Miscible with acetonitrile

Comparative Analysis

Trimethylacetic anhydride exhibits superior thermal stability compared to similar aliphatic anhydrides, with a flash point 20% higher than isobutyric anhydride (CAS 97-72-3), making it safer for high-temperature applications.

Key Applications

Industrial Uses

  • Pharmaceutical Intermediates: Acetylation agent for antibiotic synthesis
  • Polymer Chemistry: Modifier for polyester resins
  • Agrochemicals: Precursor in herbicide formulations

Functional Advantages

  • Enables controlled acylation reactions
  • Enhances product stability in polymer crosslinking
  • Improves reaction yields in sterically hindered syntheses

Industry Use Cases

Case Study 1: Pharmaceutical Synthesis

A European API manufacturer achieved 92% yield improvement in cephalosporin intermediate production by implementing trimethylacetic anhydride as the acylating agent, reducing reaction time from 18 to 8 hours.

Case Study 2: Specialty Coatings

Japanese polymer researchers developed UV-resistant automotive coatings using trimethylacetic anhydride-modified alkyd resins, demonstrating 40% longer weatherability in accelerated aging tests.

Supplier Profiles

Supplier Specifications Pricing Contact
Hubei Dahao Chemical 99% purity, 1kg-25kg packaging $100-$2,500/unit Ms. Liu: +86 13986246535
Hubei Jusheng Tech Pharma-grade, ISO-certified Custom quotes Ms. Wang: +86 18871490354
Hubei Shixing Chemical Bulk quantities (≥1000kg) $100/kg (volume discounts) Mr. Jiang: +86 18086426449

Contact for Quotation

Request custom formulations or bulk pricing:

Technical support available for formulation optimization and regulatory compliance guidance.

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