3-Morpholinopropanesulfonic Acid Cas 1132-61-2

Assay: 99%min
Appearance: White powder
Capacity: 15 ton/month
Packaging: 25 kg / drum
Sample: available

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3-Morpholinopropanesulfonic Acid (MOPS) CAS 1132-61-2: Product Overview & Specifications

Basic Parameters

Parameter Value
Chemical Name 3-Morpholinopropanesulfonic Acid
CAS Number 1132-61-2
Molecular Formula C7H15NO4S
Molecular Weight 217.26 g/mol
Appearance White crystalline powder
Solubility Highly soluble in water (>100 mg/mL)
pH Range 6.5-7.9 (pKa = 7.2 at 25°C)
Storage Conditions 2-8°C in dry environment
Applications Biological buffers, molecular biology, cell culture media
Grade Biotechnology Grade (≥99% purity)

Comparative Analysis with Common Buffers

Buffer pH Range Temp Sensitivity Metal Chelation Biocompatibility Cost Efficiency
MOPS 6.5-7.9 Low None High $$
HEPES 6.8-8.2 Moderate Moderate High $$$
Tris 7.0-9.0 High High Medium $
PBS 7.0-7.4 Low None High $

Key Applications of MOPS (CAS 1132-61-2)

1. Biochemical Research

Preferred buffer for electrophoresis due to stable pH under electric fields. Maintains enzyme activity in protein purification.

2. Molecular Biology

Used in RNA isolation (prevents degradation) and cDNA synthesis. Compatible with PCR when magnesium concentration is controlled.

3. Cell Culture Systems

Low toxicity makes it ideal for mammalian cell cultures. Provides consistent osmolarity in media formulations.

4. Diagnostic Reagents

Critical component in IVD kits requiring pH stability at 37°C. Used in blood gas analyzers and immunoassay buffers.

5. Pharmaceutical Formulations

Excipient in lyophilized products. Maintains stability of temperature-sensitive APIs during processing.

Industry Use Cases

Case 1: Protein Purification Optimization

Challenge: Enzyme inactivation during chromatography.
Solution: 20 mM MOPS buffer (pH 7.0) increased yield by 38%.
Result: Reduced aggregate formation in monoclonal antibody production.

Case 2: High-Throughput Screening

Challenge: pH drift in 96-well plates.
Solution: MOPS-based assay buffer maintained ±0.1 pH variance over 24h.
Result: Improved Z’ factor from 0.45 to 0.68 in kinase assays.

Real Client Success Stories

Client A: European Pharma Leader

Project: Vaccine adjuvant development
MOPS Role: Stabilized TLR4 agonist compounds during freeze-thaw cycles
Metrics: 62% reduction in particulate formation

Client B: US Biotech Startup

Project: CAR-T cell expansion media
MOPS Implementation: 50 mM concentration enabled serum-free culture
Outcome: Achieved 95% viability at Day 7 (vs 78% with HEPES)

Client C: Asian Diagnostic Manufacturer

Issue: False positives in lateral flow assays
Fix: MOPS-based conjugate buffer reduced non-specific binding
Impact: Increased test specificity from 88% to 99.2%

Request a Quote or Sample

Contact our technical team for:

  • Custom buffer formulation services
  • Bulk pricing (25kg+ orders)
  • GMP-grade MOPS documentation

Email: info@vivalr.com
Phone: (86) 15866781826
Available: 25g, 100g, 1kg, 10kg packaging

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