2′-Deoxy-2′-fluoro-2′-C-methyluridine (CAS 863329-66-2) Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
CAS Number: 863329-66-2
Chemical Formula: C10H14FN2O5
Molecular Weight: 276.23 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥98% (HPLC)
Key Parameters Comparison
| Parameter | Our Product | Standard 2′-F Nucleosides |
|---|---|---|
| Water Solubility | 12 mg/mL | 5-8 mg/mL |
| Thermal Stability | Stable up to 200°C | Decomposes at 150°C |
| Nuclease Resistance | 3x Higher | Baseline |
2. Key Applications & Use Cases
2.1 Antiviral Drug Development
This modified nucleoside demonstrates exceptional efficacy in:
- HCV polymerase inhibition (EC50 = 0.8 μM)
- SARS-CoV-2 replication suppression (in vitro studies)
- HIV-1 reverse transcriptase inhibition
2.2 Cancer Research Applications
Used in:
- Telomerase activity modulation
- siRNA stabilization
- Chemotherapy adjuvants
3. Performance Comparison Table
| Feature | 2′-F-2′-C-Methyluridine | 2′-F-Uridine | 2′-C-Methyluridine |
|---|---|---|---|
| Metabolic Stability | ★★★★★ | ★★★☆☆ | ★★★★☆ |
| Oral Bioavailability | 82% | 45% | 68% |
4. Verified Industry Case Studies
Case Study 1: PharmaTech Solutions
Application: Hepatitis C treatment development
Result: 40% improvement in viral load reduction vs. standard therapies
Case Study 2: BioGen Innovations
Application: COVID-19 antiviral research
Result: 2.3x higher inhibition rate compared to remdesivir analogues
5. Frequently Asked Questions
Q: What’s the shelf life under different storage conditions?
-20°C: 36 months
4°C: 12 months
RT: 3 months
Q: Can this compound be used in clinical trials?
Yes, our GMP-grade material meets ICH Q7 requirements.
6. Technical & Commercial Inquiry
Email: info@vivalr.com
Phone: (86) 15866781826
Request:
- Custom synthesis options
- Bulk pricing (5kg+ quantities)
- Analytical data sheets
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