1. Product Overview & Specifications

1,1′-Carbonyldiimidazole (CDI) (CAS 530-62-1) is a highly reactive coupling agent widely used in peptide synthesis, pharmaceutical manufacturing, and polymer chemistry. Key specifications include:

2. Key Applications & Use Cases

2.1 Peptide Bond Formation

CDI activates carboxylic acids to form imidazolides, enabling efficient amide coupling under mild conditions with minimal racemization.

2.2 Pharmaceutical Intermediates

Used in synthesizing ACE inhibitors, β-lactam antibiotics, and antiviral agents due to its low toxicity and high selectivity.

3. CDI vs. Alternative Coupling Agents

4. Industry Case Studies

Case 1: XYZ Biotech (Peptide Drug Development)

Challenge: Low yield in somatostatin analog synthesis.
Solution: CDI-mediated coupling at 0°C in DMF.
Result: 92% yield vs. 78% with DIC/HOBt.

Case 2: ABC Polymers (Polyurethane Production)

CDI enabled solvent-free prepolymer synthesis, reducing VOC emissions by 40%.

5. Usage Optimization Strategies

• Maintain anhydrous conditions (≤50 ppm H₂O)
• Use 1.1-1.5 eq CDI relative to carboxylic acid
• Monitor reaction progress via FTIR (disappearance of C=O at 1700 cm⁻¹)

6. Contact Our Technical Team

For batch-specific specifications or custom synthesis requirements:
Email: info@vivalr.com
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