Methyl Acetoacetate (CAS 105-45-3): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Methyl Acetoacetate | Ethyl Acetoacetate |
|---|---|---|
| CAS Number | 105-45-3 | 141-97-9 |
| Molecular Formula | C5H8O3 | C6H10O3 |
| Boiling Point | 169°C | 181°C |
| Flash Point | 62°C | 68°C |
| Solubility | Miscible in organic solvents | Limited in polar solvents |
Advantages: Higher reactivity in ketonic condensation reactions vs. ethyl derivative.
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates
Critical in synthesizing active pharmaceutical ingredients (APIs) like antimalarials and anticoagulants.
Agrochemical Synthesis
Used in production of herbicides and fungicides due to excellent nucleophilic reactivity.
Flavor & Fragrance Manufacturing
Key component in fruit flavorants (strawberry, apple) and premium perfumes.
3. Step-by-Step Usage Guidelines
API Synthesis Example
- Charge reactor with 1.2 molar equivalents under nitrogen
- Maintain temperature at 60-65°C during condensation
- Monitor reaction progress via HPLC
Safety Protocols
- Use PPE (gloves, goggles)
- Store in corrosion-resistant containers
4. Real-World Case Studies
Case 1: Indian Pharma Manufacturer
Challenge: Needed high-purity grade for GMP production
Solution: Supplied 99.8% HPLC-grade material
Result: 23% yield improvement
Case 2: German Agrochemical Company
Challenge: Scaling production of new fungicide
Solution: Custom bulk packaging solutions
Result: 15% cost reduction
5. Contact for Custom Solutions
Request technical specifications or pricing:
info@vivalr.com
(86) 15866781826
ISO 9001-certified production | 24hr quote response
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