4-Dimethylaminopyridine / DMAP Cas 1122-58-3
Assay: ≥99%
Appearance: White to white crystals
Capacity: 1000 MT per year
Packaging: 25kg/Cardboard drum
Sample: available
related documents:
COA of 4-Dimethylaminopyridine
TDS of 4-Dimethylaminopyridine
Request for product documents
4-Dimethylaminopyridine (DMAP) Cas 1122-58-3: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
4-Dimethylaminopyridine (DMAP) (CAS 1122-58-3) is a highly efficient nucleophilic catalyst widely used in organic synthesis. Below are its key parameters:
| Parameter | DMAP Specification |
|---|---|
| Molecular Formula | C7H10N2 |
| Molecular Weight | 122.17 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥99% (HPLC) |
| Melting Point | 108-112°C |
| Solubility | Soluble in chloroform, DCM, THF; slightly soluble in water |
Competitive Comparison
| Catalyst | Reaction Rate | Thermal Stability | Typical Yield |
|---|---|---|---|
| DMAP | High | Stable up to 150°C | 85-95% |
| Pyridine | Low | Stable up to 115°C | 60-75% |
| Imidazole | Medium | Stable up to 130°C | 70-85% |
2. Key Applications & Use Cases
Primary Applications:
- Acylation Reactions: Accelerates esterification and amidation processes
- Pharmaceutical Intermediates: Critical in synthesizing antibiotics and antivirals
- Polymer Chemistry: Enhances polycondensation efficiency
- Asymmetric Synthesis: Facilitates chiral compound production
Operational Guidelines:
- Typical dosage: 0.1-5 mol% relative to substrate
- Optimal reaction temperature: 20-80°C
- Compatible with aprotic solvents (DCM, THF, DMF)
- Post-reaction removal: Acidic aqueous wash recommended
3. Industry Case Studies
Case 1: Pharmaceutical Manufacturer (Shanghai)
Challenge: Low yield (62%) in atorvastatin intermediate synthesis
Solution: DMAP implementation at 2 mol% loading
Result: Yield increased to 89% with 99% purity
Case 2: Specialty Chemical Producer (Germany)
Challenge: Slow polymerization kinetics in polyimide production
Solution: DMAP-assisted polycondensation at 1.5 mol%
Result: Reaction time reduced by 40% with improved MW distribution
4. Technical Inquiry & Ordering
Request Custom Specifications or Bulk Quotes:
Email: info@vivalr.com
Tel: (86) 15866781826
Why Choose Us?
• Pharmaceutical-grade DMAP (ISO 9001 certified)
• Custom particle size distributions available
• Technical support team with 15+ years experience
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