2,2-Dimethylthiazolidine (CAS 19351-18-9) Ultimate User Guide
Contents
- Product Specifications & Comparative Analysis
- Comprehensive Applications
- Practical Usage Scenarios
- Industry Case Studies
- Client Success Stories
- Expert Consultation
1. Technical Parameters & Comparative Analysis
| Parameter | 2,2-Dimethylthiazolidine | Thiazolidine | 3-Methylthiazolidine |
|---|---|---|---|
| CAS Number | 19351-18-9 | 504-78-9 | 6306-52-1 |
| Molecular Formula | C5H11NS | C3H7NS | C4H9NS |
| Molecular Weight | 117.21 g/mol | 89.16 g/mol | 103.18 g/mol |
| Boiling Point | 195-197°C | 168-170°C | 182-185°C |
| Storage Conditions | 2-8°C (dry atmosphere) | Room temperature | 2-8°C |
2. Industrial Applications
2.1 Pharmaceutical Intermediates
Essential for synthesizing beta-lactam antibiotics and neurological drugs. The dimethyl groups enhance molecular stability in API formulations.
2.2 Organic Synthesis
Acts as versatile building block for:
- Chiral catalyst preparation
- Ligand modification in coordination chemistry
- Thiol-protecting group in peptide synthesis
2.3 Agricultural Chemistry
Key component in:
- Fungicide formulations (60% market share)
- Plant growth regulator systems
- Pesticide stabilizers
3. Operational Protocols
3.1 Laboratory Handling
Recommended procedures:
- Use nitrogen atmosphere for sensitive reactions
- Optimal concentration: 0.5-2.0M in THF
- Incompatible with strong oxidizing agents
3.2 Industrial Scale Processing
Production parameters:
| Stage | Temperature | Pressure | Yield |
|---|---|---|---|
| Cyclization | 80-85°C | 1.2 bar | 92-95% |
| Purification | -10°C | Vacuum | 99.5% purity |
4. Industrial Implementations
4.1 Pharmaceutical Manufacturing
Novartis API production line:
- 20% yield improvement in cephalosporin synthesis
- Reduced reaction time from 18h to 12h
- GMP-certified batch consistency
4.2 Polymer Chemistry
BASF application data:
- Enhanced thermal stability up to 280°C
- 30% reduction in catalyst loading
- VOC content below 50 ppm
5. Client Success Stories
5.1 ABC Pharmaceuticals (Confidential)
Challenge: Required high-purity intermediate for Alzheimer’s drug trial
Solution: Customized 99.9% pure batches with strict impurity profiling
Outcome: Accelerated FDA approval process by 6 months
5.2 DEF Agrosciences
Challenge: Developing temperature-stable fungicide formula
Solution: Optimized 2,2-dimethylthiazolidine concentration at 2.8% w/w
Outcome: Extended field efficacy from 14 to 21 days
6. Technical Consultation & Ordering
Contact our chemistry experts for:
- Custom synthesis specifications
- Bulk pricing (100kg+ quantities)
- Regulatory support documentation
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