2-Pyrrolidinone (CAS 616-45-5): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | 2-Pyrrolidinone | DMF | NMP |
|---|---|---|---|
| CAS Number | 616-45-5 | 68-12-2 | 872-50-4 |
| Boiling Point | 245°C | 153°C | 202°C |
| Flash Point | 113°C | 58°C | 96°C |
| Viscosity (25°C) | 13.3 mPa·s | 0.92 mPa·s | 1.65 mPa·s |
| LD50 (Oral Rat) | 6,800 mg/kg | 4,200 mg/kg | 5,000 mg/kg |
Key differentiators: Superior thermal stability, reduced toxicity profile, and enhanced solvent power for polar polymers.
2. Key Applications & Industrial Uses
Pharmaceutical Intermediate Synthesis
Preferred solvent for API crystallization due to high purity (≥99.9%) and low metal ion content (<1 ppm).
Electronics Manufacturing
Critical component in photoresist strippers (5-15% concentration) for semiconductor fabrication.
Polymer Engineering
Reactive diluent in polyimide production, enabling viscosity reduction by 30-40% versus traditional solvents.
4. Implementation Case Studies
Case 1: High-Purity Lithium Battery Electrolytes
Implementation: Used as co-solvent (10% v/v) in LiPF6-based electrolytes
Outcome: Increased ionic conductivity by 18% at -20°C operation
Case 2: Antiviral Drug Synthesis
Implementation: Solvent medium for nucleoside phosphorylation
Outcome: Achieved 92% yield with ≤0.3% residual solvent
5. Verified Customer Success Stories
Shanghai PharmaTech Co., Ltd.
Application: Voriconazole intermediate purification
Results: Reduced processing time by 35% vs. DMF-based process
Testimonial: “Consistent HPLC purity ≥99.5% across 12 batches”
Shenzhen Circuit Materials Inc.
Application: PCB photoresist formulation
Results: 22% improvement in line width resolution
Testimonial: “Critical for our 5G antenna etching processes”
6. Technical Consultation & Ordering
Contact our chemical engineers for application-specific solutions:
Email: info@vivalr.com
Tel: (86) 15866781826
Request: Custom purity grades (99.5%-99.99%), bulk packaging options (200kg drums to ISO tanks).
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