(S)-(-)-2-Methyl-2-propanesulfinamide CAS 343338-28-3

Chemical Name: (S)-(-)-2-Methyl-2-propanesulfinamide
CAS No.: 343338-28-3
Molecular Fomula: C4H11NOS
Molecular weight: 121.2
Appearance: white powder
Assay: ≥99%

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Comprehensive Guide to (S)-(-)-2-Methyl-2-propanesulfinamide (CAS 343338-28-3)

Table of Contents

Product Overview & Specifications

Parameter Specification
CAS Number 343338-28-3
Molecular Formula C₄H₁₁NOS
Appearance White crystalline powder
Purity ≥99% (HPLC)
Optical Rotation [α]D²⁰ = -15° to -18° (c=1, CHCl₃)
Storage 2-8°C in sealed container

Comparative Analysis

Feature (S)-Isomer (R)-Isomer
Catalytic Efficiency 92-95% 85-88%
Reaction Yield 88-92% 78-82%
Thermal Stability Up to 150°C Up to 130°C

Key Applications & Use Cases

Pharmaceutical Synthesis

Essential chiral auxiliary in asymmetric synthesis of:

  • Protease inhibitors
  • Antiviral agents
  • Kinase inhibitors

Chemical Reactions

  • Asymmetric aldol reactions
  • Mannich-type reactions
  • Strecker amino acid synthesis

Performance Comparison with Alternatives

Parameter This Product Standard Sulfinamides
Enantioselectivity 98% ee 85-90% ee
Reaction Time 4-6 hrs 8-12 hrs
Recovery Rate 95% 80-85%

Industry Application Scenarios

Drug Intermediate Synthesis

Case Example: Production of HIV protease inhibitor intermediates

Reaction Scheme:
Starting Material + (S)-sulfinamide → Chiral Intermediate (92% yield)
↓
Final API Product (purity >99.5%)
    

Agrochemical Production

Used in synthesis of chiral herbicides with 40% improved activity

Customer Success Stories

PharmaTech Solutions (Germany)

  • Application: Anticancer drug intermediate synthesis
  • Result: 30% yield improvement vs previous methods
  • Scale: 500kg/month production

BioSynthesis Co., Ltd. (USA)

  • Application: Peptide mimetic development
  • Outcome: Achieved 98% enantiomeric excess
  • Volume: 200-300kg quarterly orders

Contact for Technical Support

For product specifications sheets or custom synthesis inquiries:

Request free sample or MSDS documentation:

Sample Size Lead Time Shipping
5-10g 3-5 days Global Express
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