Diphenyl Azidophosphate (DPPA) CAS 26386-88-9

Diphenyl Azidophosphate (DPPA) CAS 26386-88-9 Comprehensive Guide

Table of Contents

• 1. Product Overview & Specifications
• 2. Key Applications
• 3. Operational Guidelines
• 4. Industry Case Studies
• 5. Client Success Stories
• 6. Contact for Technical Consultation

1. Product Overview & Specifications

Storage: Maintain in airtight containers at 2-8°C, protected from light and moisture.

2. Key Applications

2.1 Organic Synthesis

Primary uses in Curtius rearrangement reactions and preparation of acyl azides through carboxyl activation.

2.2 Pharmaceutical Intermediates

Critical component for synthesizing macrocyclic lactams and aldehyde reductase inhibitors.

2.3 Peptide Chemistry

Employed as coupling agent in solid-phase peptide synthesis (SPPS) with minimized racemization.

3. Operational Guidelines

3.1 Mitsunobu Reaction Modification

Optimal conditions: 1:1.2 molar ratio of alcohol to DPPA with DBU in anhydrous THF at 0-5°C.

3.2 Safety Protocols

Requires handling in fume hood with nitrile gloves. Incompatible with strong oxidizers and acids.

4. Industry Case Studies

4.1 Antiviral Drug Production

Used in synthesis of oseltamivir phosphate intermediates, achieving 92% yield improvement over traditional methods.

4.2 Advanced Material Development

Key component in creating self-healing polymers through azide-alkyne click chemistry.

5. Client Success Stories

5.1 EuroPharma Solutions

“DPPA implementation reduced our peptide synthesis cycle time by 40% while maintaining 99.5% enantiomeric excess.”

5.2 Shanghai BioTech Institute

“Achieved breakthrough in targeted cancer therapeutics using DPPA-mediated antibody-drug conjugation.”

6. Contact for Technical Consultation

For bulk pricing, SDS documentation, or application support:
Email: info@vivalr.com
Tel: (86) 15866781826