Tetrabutylammonium Bromide (CAS 1643-19-2): Technical Guide & Industry Applications
Table of Contents
1. Product Overview & Specifications
| Parameter | Tetrabutylammonium Bromide | Tetraethylammonium Bromide |
|---|---|---|
| CAS Number | 1643-19-2 | 71-91-0 |
| Molecular Formula | C16H36BrN | C8H20BrN |
| Molecular Weight | 322.37 g/mol | 210.16 g/mol |
| Appearance | White hygroscopic crystals | White crystalline powder |
| Melting Point | 102-106°C | 285°C (dec.) |
| Water Solubility | 600 g/L (20°C) | 1,430 g/L (20°C) |
2. Key Applications & Functional Uses
Core Industrial Functions:
- Phase Transfer Catalyst: Enables reactions between immiscible phases in pharmaceutical synthesis
- Ion-Pairing Reagent: Critical for HPLC analysis of ionic compounds
- Pharmaceutical Intermediate: Used in synthesis of Bacampicillin, Sultamicillin, and Dapagliflozin
- Electrochemical Applications: Electrolyte additive in battery systems
Performance Advantages:
- Superior catalytic efficiency in nucleophilic substitution reactions
- Enhanced reaction rates under mild conditions
- Compatible with polar aprotic solvents (DMF, DMSO)
3. Operational Case Studies
Case 1: Antibiotic Synthesis Optimization
A European pharmaceutical manufacturer achieved 38% yield improvement in Bacampicillin production through TBAB-mediated phase transfer catalysis, reducing reaction time from 12h to 6h at 60°C.
Case 2: HPLC Method Development
Analytical laboratory validated a USP-compliant method for ionic drug quantification using 10mM TBAB in mobile phase (ACN:buffer 65:35), achieving resolution >2.0 for critical pairs.
4. Industry Client Implementations
Client A: Hubei Changxinsheng Chemical Co., Ltd.
- Application: Bulk API synthesis for diabetes medications
- Scale: 500kg/month TBAB consumption
- Result: 22% reduction in side products vs. traditional catalysts
Client B: Shandong Jinyueyuan New Materials
- Application: Lithium-ion battery electrolyte formulation
- Specification: 99.5% purity, <50ppm moisture
- Outcome: 15% improvement in battery cycle life
5. Technical Support & Inquiry
For technical specifications, bulk pricing, or customized solutions:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Request product samples or MSDS documentation through our 24-hour response service.



评论
目前还没有评论。