Chemical Name: Fmoc-L-Arg(Pbf)-OH
CAS No.: 154445-77-9
Molecular Fomula: C34H40N4O7S
Molecular weight: 648.77
Appearance: solid
Assay: ≥99.0
1. Product Specifications & Comparative Analysis
2. Functional Applications & Usage Scenarios
3. Operational Case Studies
4. Industry Adoption & Client Implementations
5. Procurement Guidance & Technical Consultation
Parameter | Fmoc-L-Arg(Pbf)-OH | Standard Fmoc-AA |
---|---|---|
CAS Number | 154445-77-9 | Varies |
Molecular Formula | C34H46N4O7S | Dependent on AA |
Purity Grade | ≥98% (HPLC) | 95-98% |
Side Chain Protection | Pbf Group | Standard Groups |
Peptide Synthesis Applications:
- Solid-phase peptide synthesis (SPPS) backbone
- Critical component in GPCR-targeting peptides
- HIV protease inhibitor development
- Vaccine adjuvant peptide sequences
Pharmaceutical Research:
- Controlled drug delivery systems
- Antibody-drug conjugate (ADC) linkers
- Tumor-targeting peptide frameworks
Case 1: Anticoagulant Peptide Development
Research team optimized thrombin inhibition rates by 38% through strategic Pbf-protected arginine positioning in heparin-binding domains.
Case 2: Antimicrobial Peptide Production
Manufacturing yield increased from 67% to 89% by implementing temperature-controlled Fmoc removal cycles during SPPS processes.
Client A: PeptideTech Inc. (USA)
- Application: VIP receptor agonists
- Implementation: 15kg batch production
- Outcome: 92% purity achieved with 0.3% diastereomer content
Client B: BioSynth Laboratories (EU)
- Application: COVID-19 spike protein analogs
- Implementation: Continuous flow synthesis adaptation
- Outcome: 40% reduction in solvent consumption
Bulk Order Specifications:
- MOQ: 100g (GMP grade)
- Lead Time: 3-5 weeks
- Stability: 24 months @ -20°C
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