xant phos cas 161265-03-8

1. Product Overview & Specifications

Xantphos (CAS 161265-03-8) is a bisphosphine ligand widely used in transition metal-catalyzed cross-coupling reactions. Below are its key specifications:

2. Key Applications of Xantphos

Xantphos is critical in:

• Suzuki-Miyaura Coupling: Enhances aryl-aryl bond formation efficiency.
• Buchwald-Hartwig Amination: Facilitates C-N bond formation in drug intermediates.
• Hydroamination: Accelerates asymmetric synthesis of chiral amines.

3. Usage Guidelines & Best Practices

• Use under inert atmosphere (N2/Ar) to prevent oxidation.
• Optimal catalyst loading: 1-5 mol% with Pd(0) or Ni(0) precursors.
• Compatible with solvents: toluene, THF, or dioxane at 80-110°C.

4. Real-World Case Studies

Case 1: PharmaTech Solutions

Challenge: Low yield in axitinib intermediate synthesis.
Solution: Xantphos-Pd catalyzed Suzuki coupling (3 mol% loading).
Result: Yield increased from 52% to 89%.

Case 2: ChemSolutions Ltd.

Challenge: Uncontrolled selectivity in OLED material synthesis.
Solution: Xantphos-Ni system for regioselective C-H activation.
Result: Achieved 95% regioselectivity.

5. Inquiry & Contact

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