Methyl trifluoroacetate CAS 431-47-0

Chemical Name: Methyl trifluoroacetate
CAS No.: 431-47-0
Molecular Formula: C3H3F3O2
Molecular weight: 128.05
Appearance: Colorless transparent liquid
Assay: 99%min

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Methyl Trifluoroacetate (CAS 431-47-0) Comprehensive Guide

Table of Contents

1. Product Overview & Specifications

Parameter Methyl Trifluoroacetate Methyl Acetate Methyl Trichloroacetate
CAS Number 431-47-0 79-20-9 598-99-2
Molecular Formula C3H3F3O2 C3H6O2 C3H3Cl3O2
Molecular Weight 142.05 g/mol 74.08 g/mol 197.41 g/mol
Boiling Point 40-42°C 57°C 152°C
Flash Point -4°C -10°C 72°C
Density 1.273 g/cm³ 0.932 g/cm³ 1.492 g/cm³

2. Key Applications & Industry Uses

2.1 Pharmaceutical Intermediate

Widely used in synthesizing fluorinated drug molecules due to its superior leaving group properties in nucleophilic substitution reactions.

2.2 Agrochemical Production

Essential for creating fluorinated pesticides with enhanced environmental stability and bioactivity.

2.3 Specialty Chemical Synthesis

Serves as trifluoromethylating agent in advanced material production including liquid crystals and OLED materials.

3. Performance Comparison with Similar Esters

Feature Methyl Trifluoroacetate Ethyl Trifluoroacetate
Reaction Rate Faster acyl transfer Slower kinetics
Byproduct Formation Lower (stable CF3 group) Higher
Solvent Compatibility Wider polarity range Limited to polar aprotic

4. Operational Guidelines & Safety Protocols

4.1 Storage Requirements

Store in sealed containers under inert gas (N2/Ar) at 2-8°C with humidity below 40% RH.

4.2 Handling Precautions

Use chemical-resistant PPE including fluoropolymer gloves and full-face respirators with A1B1E1K1 filters.

5. Real-World Case Studies

5.1 Pharma Intermediate Production (Client: EuroFarma Ltd.)

Challenge: Required high-purity trifluoromethylated intermediates for antiviral drug development
Solution: Implemented methyl trifluoroacetate in continuous flow reactors
Result: 92% yield improvement vs batch processing

5.2 Electronic Materials Synthesis (Client: NanoFlux Technologies)

Challenge: Needed low-boiling fluorinating agent for vacuum deposition processes
Solution: Adopted methyl trifluoroacetate as precursor
Result: Reduced process temperature by 35°C with 99.7% purity

6. Technical Inquiry & Procurement Support

For technical specifications sheets or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826

Request customized documentation:
• COA (Certificate of Analysis)

• MSDS (Material Safety Data Sheet)
• Custom synthesis protocols

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