Tetrabutylammonium Fluoride Cas 429-41-4
Chemical Name: Tetrabutylammonium fluoride
CAS No.: 429-41-4 / 87749-50-6
Molecular Formula: C16H36FN
Molecular weight:261.46
Appearance: White or yellow ceraceous
Assay: ≥98%
related documents:
COA of Tetrabutyl ammonium fluoride
TDS of Tetrabutyl ammonium fluoride
Request for product documents
Tetrabutylammonium Fluoride (CAS 429-41-4): Technical Guide & Application Insights
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | Tetrabutylammonium Fluoride | Alternative Fluorination Agents |
|---|---|---|
| CAS Number | 429-41-4 | Varies by compound |
| Molecular Formula | C16H36FN | Typically simpler structures |
| Molecular Weight | 261.462 g/mol | Generally lower MW |
| Appearance | White to yellow hygroscopic wax | Powders/liquids common |
| Melting Point | 62-63°C | Wider range (50-300°C) |
| Solubility | THF, water, acetonitrile | Limited solvent compatibility |
2. Key Applications & Functional Properties
Core Functions:
- Silicon Deprotection: Efficient cleavage of silyl ether protecting groups under mild conditions
- Fluorination Catalyst: Enables nucleophilic fluorination in SN2 reactions
- Phase Transfer Agent: Facilitates reactions between immiscible phases in alkylation/elimination processes
Industry-Specific Uses:
- Pharmaceutical intermediates synthesis
- Liquid crystal material production
- Specialty polymer modification
3. Practical Use Cases in Organic Synthesis
Case 1: Deprotection in Antiviral Drug Synthesis
Used at 0.1M concentration in THF to remove tert-butyldimethylsilyl (TBDMS) groups from nucleoside intermediates, achieving >95% yield under nitrogen atmosphere.
Case 2: Fluorinated Polymer Production
Employed as phase transfer catalyst (0.5 mol%) in interfacial polymerization of fluorinated diamines, reducing reaction time from 48h to 12h.
4. Industry Client Success Stories
Wuhan Jiye Sheng Chemical Co., Ltd.
- Application: Manufacturing of liquid crystal intermediates
- Result: 30% reduction in side products through optimized TBAF-mediated fluorination
- Scale: 500kg/month production
Hubei Yaoshuoquan Chemical
- Application: Synthesis of antitumor drug candidates
- Challenge: Selective deprotection of sensitive substrates
- Solution: Custom 1M THF solution with stabilized moisture content <50ppm
5. Contact for Customized Solutions
Request technical specifications sheets or discuss bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826



评论
目前还没有评论。