levosimendan cas 141505-33-1

Chemical Name:Levosimendan
CASNo.: 141505-33-1
Molecular Formula: C14H12N6O
Molecular Weight: 280.28
Appearance:Yellow crystalline powder, odorless, tasteless

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Levsimendan (CAS 141505-33-1) Product Guide

Table of Contents

1. Product Overview & Specifications

Levsimendan (CAS 141505-33-1) is a calcium sensitizer and vasodilator used to treat acute decompensated heart failure. Below are its key parameters:

Parameter Details
Chemical Name (-)-[[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile
CAS Number 141505-33-1
Molecular Formula C14H12N6O
Molecular Weight 280.29 g/mol
Appearance Yellow crystalline powder
Solubility Soluble in DMSO, ethanol; insoluble in water
Storage 2-8°C, protected from light

Comparative Analysis

Feature Levsimendan Milrinone Dobutamine
Mechanism Calcium sensitizer PDE3 inhibitor β1-adrenergic agonist
Half-Life 1 hour (active metabolite: 80 hours) 2.3 hours 2 minutes
Renal Adjustment Not required Required Not required

2. Key Applications & Clinical Uses

Levsimendan is primarily used in:

  • Acute Heart Failure: Improves cardiac output without increasing oxygen demand.
  • Post-Cardiac Surgery: Reduces risk of low cardiac output syndrome.
  • Pulmonary Hypertension: Acts as a pulmonary vasodilator.

3. Usage Guidelines & Best Practices

  • Dosing: 12 μg/kg initial bolus, followed by 0.1 μg/kg/min infusion.
  • Contraindications: Severe hypotension, tachycardia.
  • Drug Interactions: Avoid with other vasodilators.

4. Case Studies

Case 1: European Cardiac Center (2023)

100 patients with acute decompensated heart failure showed a 40% reduction in rehospitalization rates after Levsimendan therapy.

Case 2: India Hospital Trial (2024)

Post-cardiac surgery patients experienced 25% higher ejection fraction compared to dobutamine.

5. Client Success Stories

Client A: Germany Pharma Co., Ltd.

“Levsimendan reduced ICU stays by 2 days in 80% of cases. Ongoing orders since 2022.”

Client B: Brazil Medical Research Institute

“Used in 50+ pulmonary hypertension trials with 90% efficacy. Planning bulk purchase for 2025.”

6. Request a Quote or Sample

Contact us for pricing, COA, or clinical data:

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