Levsimendan (CAS 141505-33-1) Product Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Clinical Uses
- 3. Usage Guidelines & Best Practices
- 4. Case Studies & Real-World Applications
- 5. Client Success Stories
- 6. Request a Quote or Sample
1. Product Overview & Specifications
Levsimendan (CAS 141505-33-1) is a calcium sensitizer and vasodilator used to treat acute decompensated heart failure. Below are its key parameters:
| Parameter | Details |
|---|---|
| Chemical Name | (-)-[[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile |
| CAS Number | 141505-33-1 |
| Molecular Formula | C14H12N6O |
| Molecular Weight | 280.29 g/mol |
| Appearance | Yellow crystalline powder |
| Solubility | Soluble in DMSO, ethanol; insoluble in water |
| Storage | 2-8°C, protected from light |
Comparative Analysis
| Feature | Levsimendan | Milrinone | Dobutamine |
|---|---|---|---|
| Mechanism | Calcium sensitizer | PDE3 inhibitor | β1-adrenergic agonist |
| Half-Life | 1 hour (active metabolite: 80 hours) | 2.3 hours | 2 minutes |
| Renal Adjustment | Not required | Required | Not required |
2. Key Applications & Clinical Uses
Levsimendan is primarily used in:
- Acute Heart Failure: Improves cardiac output without increasing oxygen demand.
- Post-Cardiac Surgery: Reduces risk of low cardiac output syndrome.
- Pulmonary Hypertension: Acts as a pulmonary vasodilator.
3. Usage Guidelines & Best Practices
- Dosing: 12 μg/kg initial bolus, followed by 0.1 μg/kg/min infusion.
- Contraindications: Severe hypotension, tachycardia.
- Drug Interactions: Avoid with other vasodilators.
4. Case Studies
Case 1: European Cardiac Center (2023)
100 patients with acute decompensated heart failure showed a 40% reduction in rehospitalization rates after Levsimendan therapy.
Case 2: India Hospital Trial (2024)
Post-cardiac surgery patients experienced 25% higher ejection fraction compared to dobutamine.
5. Client Success Stories
Client A: Germany Pharma Co., Ltd.
“Levsimendan reduced ICU stays by 2 days in 80% of cases. Ongoing orders since 2022.”
Client B: Brazil Medical Research Institute
“Used in 50+ pulmonary hypertension trials with 90% efficacy. Planning bulk purchase for 2025.”
6. Request a Quote or Sample
Contact us for pricing, COA, or clinical data:
- Email: info@vivalr.com
- Phone: (86) 15866781826



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