Chemical Name: Pivaloyl Chloride
Synonyms: Trimethylacetyl chloride; Pivalic acid chloride; 2,2-Dimethylpropanoyl Chloride
CAS No.: 3282-30-2
Molecular Fomula: C5H9ClO
Molecular weight: 120.58
Parameter | Specification | Industry Benchmark |
---|---|---|
CAS Number | 3282-30-2 | N/A |
Molecular Formula | C5H9ClO | Similar acyl chlorides: C3H5ClO (Acetyl chloride) |
Molecular Weight | 120.58 g/mol | 78.50 g/mol (Acetyl chloride) |
Boiling Point | 105-107°C | 51-52°C (Acetyl chloride) |
Flash Point | 8.9°C | 4°C (Acetyl chloride) |
Purity Grade | ≥99.0% | Standard: ≥98.5% |
Key intermediate for β-lactam antibiotics:
- Ampicillin derivatives
- Cephalosporin antibiotics (Cefazolin, Cephalexin)
- Dual-function prodrug development
- Primary intermediate for carbamate insecticides (Triazamate)
- Herbicide precursor (Isoxazolidinone derivatives)
- Fungicide synergist
- Initiator for radical polymerization (tert-Butyl perpivalate)
- Surface modification agent for specialty plastics
- Cross-linking accelerator
Case 1: Pharmaceutical intermediate synthesis
- Reaction yield improvement: 72% → 89%
- Byproduct reduction through temperature-controlled acylation
- Mandatory PPE: Chemically resistant gloves (Butyl rubber), full-face shield
- Emergency neutralization procedure: 5% sodium bicarbonate solution
- Storage requirements: Nitrogen atmosphere, temperature <25°C
- Application: Cephalosporin API production
- Achievement: 32% cost reduction in side-chain protection
- Annual consumption: 18 metric tons
- Application: Triazamate insecticide synthesis
- Technical support: Customized distillation protocol
- Purity achieved: 99.7% (GC analysis)
- Application: High-performance polymer initiators
- Result: 40% faster curing time in composite materials
- Quality certification: ISO 9001:2015 compliant
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