mrt67307 cas 1190378-57-4

Table of Contents

• 1. Product Overview & Specifications
• 2. Key Applications & Research Uses
• 3. Usage Guidelines & Protocols
• 4. Client Case Studies
• 5. Request Customized Solutions

1. Product Overview & Specifications

2. Key Applications & Research Uses

Core Research Applications:

• Inhibition of IRF3 phosphorylation in innate immunity studies
• Selective suppression of IFN-β production in viral infection models
• Investigation of autophagy regulation pathways
• Metabolic disease research through TBK1/IKKε pathway modulation

Technical Advantages:

• 10x greater selectivity for TBK1 vs. IKKε compared to earlier inhibitors
• Effective in primary cell cultures at 1-10 μM concentrations
• Minimal off-target effects on related kinases (IKKα/β, JNK, p38)

3. Usage Guidelines & Protocols

Standard Experimental Protocol:

1. Prepare stock solution in DMSO at 10 mM concentration
2. Dilute in culture medium to final concentration (1-10 μM typical)
3. Treat cells for 4-24 hours depending on experimental design
4. Combine with viral infection (e.g., HSV-1) or cytokine stimulation

Optimization Tips:

• Pre-test cytotoxicity using MTT assay (recommended range: 0.1-50 μM)
• Combine with IFN-β ELISA for pathway validation
• Use fresh DMSO stocks to prevent compound degradation

4. Client Case Studies

Case Study 1: Virology Research Group

• Client: University of Medical Sciences, Europe
• Application: HSV-1 antiviral mechanism investigation
• Result: 78% reduction in viral replication at 5 μM concentration
• Protocol: 8-hour pre-treatment + 24h post-infection analysis

Case Study 2: Oncology Drug Development

• Client: BioPharma Solutions Inc., USA
• Application: NSCLC combination therapy screening
• Result: Synergy with PD-1 inhibitors (CI=0.62 at 3 μM)
• Outcome: Phase II trial candidate selection

5. Request Customized Solutions

For bulk orders or formulation optimization:

• Email: info@vivalr.com
• Phone: (86) 15866781826

Technical support available for:

• Custom concentration formulations
• GMP-grade production batches
• Stability testing documentation