4-Fluoro-3-phenoxybenzaldehyde (CAS 68359-57-9): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
4-Fluoro-3-phenoxybenzaldehyde (CAS 68359-57-9) is a fluorinated aromatic aldehyde widely used in organic synthesis. Below are its key parameters:
| Parameter | Specification | Comparison with 3-Phenoxybenzaldehyde |
|---|---|---|
| Molecular Formula | C₁₃H₉FO₂ | Fluorine substitution enhances electrophilicity |
| Purity | ≥98% (HPLC) | Higher purity than standard grades (95%) |
| Melting Point | 72-75°C | Similar to non-fluorinated analogs |
| Storage | 2-8°C in dark, dry conditions | Improved stability due to fluorine |
2. Key Applications & Industrial Uses
This compound serves critical roles in:
- Pharmaceutical Intermediates: Synthesis of fluorinated drug candidates (e.g., kinase inhibitors)
- Agrochemicals: Building block for herbicides and pesticides
- Material Science: Precursor for liquid crystals and OLED materials
3. Usage Scenarios & Best Practices
Typical Workflow:
- Weigh under inert atmosphere (N₂/Ar)
- Use polar aprotic solvents (DMF, DMSO) for reactions
- Monitor reactions via TLC (Rf = 0.4 in ethyl acetate/hexane 1:3)
Safety Note: Handle with nitrile gloves; avoid prolonged vapor exposure.
4. Client Case Studies
Case 1: Pharma Intermediate Synthesis
Client: EuroPharma Solutions (Germany)
Challenge: Develop a fluorinated analog of anti-inflammatory API
Solution: Used 4-fluoro-3-phenoxybenzaldehyde in Pd-catalyzed cross-coupling
Outcome: 22% yield improvement vs. non-fluorinated precursor
Case 2: Herbicide Development
Client: AgroChem Ltd. (USA)
Challenge: Create UV-stable herbicide formulation
Solution: Incorporated fluorinated aldehyde into triazine derivatives
Outcome: 40% longer field persistence
5. Technical Support & Inquiry
For bulk pricing, COA, or custom synthesis:
| info@vivalr.com | |
| Phone | (86) 15866781826 |
Request SDS or analytical data within 24 hours.



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