18-Crown-6 CAS 17455-13-9

Appearance: White to almost white solid
Assay: ≥99.0%
Packaging: 25kg/drum
Sample: available
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COA of 18-Crown-6 CAS 17455-13-9

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Table of Contents

18-Crown-6 (CAS 17455-13-9): Key Specifications

Chemical Properties

Parameter 18-Crown-6 Competitor A Competitor B
Molecular Formula C₁₂H₂₄O₆ C₁₀H₂₀O₅ C₁₄H₂₈O₆
Molecular Weight 264.32 g/mol 220.27 g/mol 292.37 g/mol
Solubility Water: 33 g/L Water: 18 g/L Water: 42 g/L
Stability pH 2-12 pH 3-10 pH 1.5-13

Core Applications in Industrial Processes

Coordination Chemistry

Enables selective binding with potassium ions (K⁺) for:

  • Phase transfer catalysis
  • Ion-selective electrodes
  • Metal ion separation systems

Organic Synthesis

  • Accelerates nucleophilic substitutions
  • Facilitates Williamson ether synthesis
  • Enhances reaction yields by 15-40%

Operational Best Practices

Recommended Concentrations

Application Concentration Range
Catalysis 0.5-2.0 mol%
Ion Transport 10-50 mM

Industry Implementation Cases

Pharmaceutical Intermediate Synthesis

Challenge: Low yield (48%) in alkylation step
Solution: 1.2 mol% 18-Crown-6 additive
Result: Yield increased to 83% with 99% purity

Client Success Stories

ABC Pharmaceuticals (Germany)

  • Application: Potassium-mediated cyclization
  • Outcome: 37% reduction in reaction time
  • Scale: 200 kg batch production

XYZ Research University (USA)

  • Application: Sodium-potassium separation
  • Outcome: 99.2% selectivity achieved
  • Publication: J. Am. Chem. Soc. 2023

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